What is the most common complication of esophagectomy?

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Last updated: May 7, 2025View editorial policy

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From the Guidelines

The commonest complication of oesophagectomy is respiratory complications (option 1). Following this major surgical procedure, patients frequently develop pulmonary issues including pneumonia, atelectasis, pleural effusions, and acute respiratory distress syndrome, as noted in the guidelines for the management of oesophageal and gastric cancer 1. These respiratory complications occur due to several factors, including pain from extensive incisions, impaired diaphragm movement, and poor lymphatic drainage of the pulmonary alveoli, resulting in a form of acute pulmonary oedema 1. The use of thoracic epidural anaesthesia has been shown to significantly decrease the incidence of respiratory complications 1. While anastomotic leaks, recurrent laryngeal nerve injury, and thoracic duct injury are all recognized complications of oesophagectomy, they occur less frequently than respiratory complications. Key preventive measures in the postoperative period to reduce the risk of these respiratory complications include:

  • Early mobilization
  • Aggressive pulmonary toilet
  • Incentive spirometry
  • Pain control, with the use of thoracic epidural anaesthesia being a significant factor in decreasing respiratory complications 1.

From the Research

Commonest Complication of Oesophagectomy

The commonest complication of oesophagectomy is a significant concern in the medical field. Based on the provided studies, the following points can be made:

  • Respiratory complications are a major concern after oesophagectomy, affecting about 30% of patients 2.
  • These complications can include sputum retention, pneumonia, and acute respiratory distress syndrome (ARDS) 2, 3, 4.
  • The incidence of respiratory complications is particularly high in the first five days after surgery 2.
  • Factors associated with respiratory complications include preoperative, intraoperative, and postoperative factors, such as a low pre-operative body mass index, history of cigarette smoking, and the experience of the surgeon 3.
  • Respiratory complications can have a significant impact on morbidity and mortality after oesophageal resection 2, 4.
  • However, some studies suggest that respiratory complications may not affect disease-free survival in patients with complete resection 5.

Comparison of Options

Comparing the given options:

  • Respiratory complication: supported by studies as a common complication of oesophagectomy 2, 3, 4.
  • Anastomosis leak: mentioned as a potential complication, but not as common as respiratory complications 6.
  • Recurrent laryngeal nerve injury: not mentioned in the provided studies.
  • Thoracic duct injury: not mentioned in the provided studies.

Conclusion is not allowed, so the response will be ended here.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Respiratory complications after oesophagectomy for cancer].

Revue des maladies respiratoires, 2008

Research

Respiratory complications after oesophagectomy for cancer do not affect disease-free survival.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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