Can alprazolam (Xanax) cause nocturnal diaphoresis (night sweats)?

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From the FDA Drug Label

Sweating15.123.5 Dermatological Sweating 14.4 The sweating mentioned in the drug label is not specifically described as night sweats.

  • The label does mention sweating as an adverse event, but it does not provide information on whether this occurs specifically at night.
  • Therefore, based on the available information, it is unclear if Xanax (alprazolam) can cause night sweats 1 1.

From the Research

Yes, Xanax (alprazolam) can cause night sweats as a side effect, particularly during withdrawal or as a result of its effects on the central nervous system and autonomic functions. Night sweats may occur in some individuals taking benzodiazepines like Xanax, although they are not among the most common side effects. The mechanism involves Xanax's influence on temperature regulation and autonomic functions, which can lead to sweating, including night sweats, in some cases 2.

Key Points to Consider

  • Xanax and other benzodiazepines can cause physiological dependence, leading to a withdrawal syndrome characterized by symptoms such as sweating, anxiety, and insomnia when the medication is reduced or stopped 2.
  • The risk of dependence and withdrawal symptoms, including night sweats, is higher with high doses or short-acting benzodiazepines, and can be influenced by factors such as the duration of exposure and individual susceptibility 2, 3.
  • If you experience persistent or severe night sweats while taking Xanax, it is essential to consult your healthcare provider, who may adjust your dosage, recommend taking the medication at a different time of day, or consider alternative treatments 4, 5.
  • Never stop taking Xanax suddenly, as this can lead to severe withdrawal symptoms, including more intense sweating, anxiety, and potentially dangerous effects; always work with your doctor to safely manage any side effects or to develop a gradual tapering schedule if you need to discontinue the medication 6, 3.

Management and Treatment

  • The treatment of panic disorder, for which Xanax is often prescribed, includes pharmacological interventions such as benzodiazepines and antidepressants, as well as psychological therapies like cognitive-behavioral therapy (CBT) 6, 5.
  • When considering the use of Xanax or other benzodiazepines, it is crucial to weigh the benefits against the risks, including the potential for dependence, withdrawal symptoms, and side effects like night sweats 4, 3.
  • Alternative treatments or adjustments in the treatment plan may be necessary for individuals experiencing significant side effects or withdrawal symptoms, and should be discussed with a healthcare provider 6, 5.

References

Research

The benzodiazepine withdrawal syndrome.

Addiction (Abingdon, England), 1994

Research

Panic disorder: A review of treatment options.

Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2021

Research

Pharmacological treatments in panic disorder in adults: a network meta-analysis.

The Cochrane database of systematic reviews, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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