What is a normal neutrophil count?

From the Guidelines

The normal neutrophil count in adults typically ranges from 1,500 to 8,000 cells per microliter (μL) of blood. This range is widely accepted and used as a reference in clinical practice [@1@]. Neutrophils are a crucial part of the immune system, and their count is an important indicator of the body's ability to fight infections.

Key Points to Consider

• A neutrophil count below 1,500/μL is considered neutropenia, which may increase susceptibility to infections [@1@].
• Counts above 8,000/μL indicate neutrophilia, often seen during acute infections, inflammation, or stress responses.
• Regular monitoring of neutrophil counts is important for individuals with chronic conditions, those undergoing chemotherapy, or those taking medications that can affect bone marrow function.
• Neutrophil counts should always be interpreted in the context of a complete blood count and the patient's clinical condition. In the context of managing patients with potential infections, such as those with neutropenia, antibiotic therapy should be directed toward foci of infection and the most likely pathogens [@1@]. The use of fluoroquinolones for prophylaxis in neutropenic patients is also supported by evidence [@1@]. However, the primary consideration in determining a normal neutrophil count remains the established range of 1,500 to 8,000 cells per microliter (μL) of blood.

From the Research

Normal Neutrophil Count

• A normal neutrophil count is typically considered to be above 1.5 × 10^9/L 1
• Neutropenia is defined as an absolute neutrophil count (ANC) less than 1.5 × 10^9/L, with severe neutropenia being an ANC less than 0.5 × 10^9/L 1
• The normal range for neutrophil count can vary slightly depending on the laboratory and the individual's age and health status

Factors Affecting Neutrophil Count

• Neutropenia can be caused by a variety of factors, including chemotherapy, radiation therapy, and certain medications 2, 3, 4, 5
• Infections, such as bacterial or viral infections, can also affect neutrophil count 2, 4
• The use of granulocyte colony-stimulating factor (G-CSF) can help increase neutrophil count in individuals with neutropenia 2, 3, 4, 5

Treatment and Management

• Treatment for neutropenia typically involves addressing the underlying cause of the condition 1
• The use of antibiotics and G-CSF can help manage neutropenia and prevent infections 1, 2, 4
• In some cases, hospitalization may be necessary to manage severe neutropenia and prevent complications 2, 4