From the Research
Antidepressant Options with Suboxone
When considering antidepressant options to take with Suboxone (buprenorphine and naloxone), several factors must be taken into account.
- The potential for pharmacodynamic interactions between the antidepressant and Suboxone must be considered 1.
- Newer antidepressants, such as serotonin selective reuptake inhibitors (SSRIs) and venlafaxine, have a wider therapeutic index and fewer adverse effects compared to older tricyclic antidepressants, making them potentially safer options 1.
- The selection of an antidepressant should be guided by factors such as drug tolerability, interactions, cost, depression subtype, psychiatric and medical comorbidity, and stage of life 2.
Safe Antidepressant Options
Some antidepressants may be safer to use with Suboxone due to their pharmacokinetic profile.
- Newer antidepressants, such as SSRIs and venlafaxine, are expected to have a lower risk of interactions with Suboxone compared to older antidepressants 3.
- However, the potential for interactions between Suboxone and any antidepressant should be carefully evaluated, and drug dosages may need to be adjusted based on clinical response 3.
Important Considerations
When prescribing an antidepressant with Suboxone, it is essential to:
- Consider the patient's individual characteristics, such as medical history and current prescriptions 2, 4.
- Monitor for potential adverse events and adjust treatment as needed 5.
- Be aware of the potential for interactions between Suboxone and the selected antidepressant, and adjust dosages accordingly 3.