There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the FDA Drug Label
DOSAGE AND ADMINISTRATION Administer TECENTRIQ intravenously over 60 minutes. If the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes.
When administering with chemotherapy with or without bevacizumab, administer TECENTRIQ prior to chemotherapy and bevacizumab when given on the same day.
Bevacizumab is administered at 15 mg/kg every 3 weeks.
The required dilution volume is not specified in the label for Tecentriq (atezolizumab) 1200mg/20mL or Avastin (bevacizumab) 1200mg/48mL. The delivery rate for Tecentriq is over 60 minutes for the first infusion and may be delivered over 30 minutes for subsequent infusions. The delivery rate for Avastin is not specified in the label. For the 4th cycle, the same delivery rates apply as the label does not specify changes in delivery rates based on the cycle number 1.
From the Research
Required Dilution Volume and Delivery Rate
The required dilution volume and delivery rate for Tecentriq (atezolizumab) 1200mg/20mL and Avastin (bevacizumab) 1200mg/48mL for the 4th cycle are not explicitly stated in the provided studies. However, the studies provide information on the dosing and administration of these drugs in various clinical trials.
Dosing and Administration
- Atezolizumab is administered at a dose of 1200 mg every 3 weeks 2, 3, 4, 5.
- Bevacizumab is administered at a dose of 15 mg/kg every 3 weeks 2, 3, 4 or 7.5 mg/kg every 3 weeks 5.
- The studies do not provide information on the required dilution volume and delivery rate for these drugs.
Key Points
- The studies provide information on the efficacy and safety of atezolizumab and bevacizumab in various clinical trials, but do not provide specific guidance on the required dilution volume and delivery rate.
- The dosing and administration of these drugs may vary depending on the specific clinical trial or treatment regimen.
- It is essential to consult the prescribing information and clinical guidelines for specific guidance on the administration of these drugs.