From the Guidelines
Bisoprolol is commonly known by the brand name Zebeta in the United States, and other brand names in different countries include Concor, Emcor, Monocor, and Soprol. Bisoprolol is a beta-blocker medication primarily used to treat high blood pressure and heart failure, as recommended by guidelines such as those outlined in 1 and 1. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels, which reduces heart rate, blood pressure, and strain on the heart. Some key points to consider when prescribing bisoprolol include:
- The typical starting dose for hypertension is 5 mg once daily, which may be increased to 10 mg if needed, as indicated in 1 and 1.
- For heart failure, treatment usually begins with a lower dose of 1.25 mg and is gradually increased over several weeks, as outlined in 1.
- Bisoprolol should be taken at the same time each day to maintain consistent blood levels.
- Patients should not stop taking this medication suddenly as this can worsen their condition, a precaution also noted in 1 and 1.
- Common side effects include fatigue, dizziness, and headache. It's also important to consider the guidelines for the use of beta-blockers in clinical practice, including the recommended procedure for starting a beta-blocker, as outlined in 1.
From the FDA Drug Label
DESCRIPTION Bisoprolol fumarate, USP is a synthetic, beta 1-selective (cardioselective) adrenoceptor blocking agent. The brand name for bisoprolol is not explicitly mentioned in the provided drug labels 2 2.
- Key points:
- The labels provide information on the chemical name, molecular formula, and structure of bisoprolol fumarate.
- They also describe the inactive ingredients and availability of bisoprolol fumarate tablets.
- However, they do not mention the brand name for bisoprolol.
From the Research
Brand Name for Bisoprolol
- The brand name for bisoprolol is not explicitly mentioned in the provided studies 3, 4, 5, 6, 7.
- However, the studies discuss the properties and uses of bisoprolol in the treatment of hypertension, heart failure, and other cardiovascular diseases.
- Bisoprolol is described as a cardioselective blocker that does not possess intrinsic sympathomimetic and membrane stabilizing activity 4.
- It is described as a highly selective β1-adrenoceptor antagonist with clinical indications in the management of heart failure with reduced left ventricular ejection fraction (HFrEF), ischaemic heart disease (IHD), and hypertension 7.
Properties and Uses of Bisoprolol
- Bisoprolol has been shown to be effective in reducing mortality in patients with heart failure 3, 5.
- It is also used in the treatment of hypertension, particularly in patients with concomitant disorders such as diabetes, chronic obstructive pulmonary disease, and peripheral atherosclerosis 4.
- Bisoprolol has been compared to other beta-blockers, such as carvedilol and metoprolol, in terms of its efficacy and tolerability 3, 5, 6.
- The choice of beta-blocker is important, as benefit is not a class-effect, and bisoprolol is considered one of the evidence-based beta-blockers for the treatment of systolic heart failure 3, 5.