What is the significance of an Immunoglobulin E (IgE) serum level of 3.8, indicating Hyperimmunoglobulinemia E (Elevated IgE)?

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The IgE serum level of 3.8 is within the normal reference range for adults, which typically falls between 0-100 IU/mL, and according to the most recent study 1, no specific treatment or intervention is needed for this result as it represents a normal finding. IgE (Immunoglobulin E) is an antibody produced by the immune system that plays a key role in allergic responses. Elevated IgE levels are often associated with allergic conditions such as asthma, allergic rhinitis, atopic dermatitis, or parasitic infections. Your normal result suggests that you likely don't have significant allergic sensitization or an active allergic process occurring at this time. However, it's essential to note that normal IgE levels don't completely rule out all allergies, as some individuals can have specific allergies with normal total IgE, as discussed in 2. If you're experiencing allergy symptoms despite this normal result, further specific allergy testing such as allergen-specific IgE tests or skin prick tests might be warranted, as recommended in 3. Additionally, it's crucial to consider that ultra-low IgE levels may be associated with an increased risk of malignancy, as suggested in 4, but this is not relevant in your case since your IgE level is within the normal range. Some key points to consider include:

  • Normal IgE levels are typically between 0-100 IU/mL
  • Elevated IgE levels can indicate allergic conditions or other disorders
  • Normal IgE levels do not completely rule out specific allergies
  • Further testing may be necessary if allergy symptoms persist despite normal IgE levels
  • The relationship between IgE levels and cancer risk is still being researched, but it is not a concern in your case given your normal IgE level.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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