What is the cause of rectal pus (purulent discharge)?

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Last updated: May 7, 2025View editorial policy

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Differential Diagnosis for Rectal Pus

  • Single most likely diagnosis
    • Anal abscess: This is the most common cause of rectal pus, typically resulting from an infection of the anal glands. The presence of pus usually indicates a need for drainage.
  • Other Likely diagnoses
    • Proctitis: Inflammation of the rectum can cause discharge, including pus, and can be due to infectious (bacterial, viral, or parasitic) or non-infectious causes (inflammatory bowel disease).
    • Rectal fistula: An abnormal connection between the rectum and the skin can lead to the discharge of pus from the rectum.
    • Diverticulitis: Inflammation of a diverticulum in the colon can lead to pus in the rectum, especially if the diverticulum ruptures.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Necrotizing fasciitis: A severe infection of the skin and soft tissues that can spread rapidly and is life-threatening if not promptly treated.
    • Perforated viscus: A hole in the wall of the intestine can lead to leakage of intestinal contents, including bacteria, into the abdominal cavity, causing severe infection.
    • Ischiorectal fossa abscess: Although less common, an abscess in this area can be life-threatening due to its potential to spread infection.
  • Rare diagnoses
    • Actinomycosis: A rare bacterial infection that can cause abscesses and fistulas in the rectal area.
    • Lymphogranuloma venereum (LGV): A sexually transmitted infection that can cause rectal symptoms, including pus, in its late stages.
    • Crohn's disease: A type of inflammatory bowel disease that can cause complications such as fistulas and abscesses, leading to rectal pus.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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