What is the diagnosis for a 16-year-old female presenting with acute sharp anterior left-sided chest pain, rated 9/10, associated with intermittent dyspnea and a history of substance abuse, including cocaine and methamphetamine, with no recent use?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 7, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 16-year-old Female with Chest Pain

  • Single most likely diagnosis
    • Pulmonary Embolism (PE): Although the patient has not used drugs in the past 3 months, her history of drug abuse increases her risk for PE. The sharp chest pain, shortness of breath, and vomiting are consistent with this diagnosis. The lack of cough or fever does not rule out PE.
  • Other Likely diagnoses
    • Pneumothorax: The sharp chest pain and shortness of breath could be indicative of a pneumothorax, especially given the patient's history of drug abuse, which may increase her risk for lung damage.
    • Costochondritis: The anterior chest pain could be due to costochondritis, which is an inflammation of the cartilage that connects the ribs to the sternum. This condition is common in adolescents and can cause sharp chest pain.
    • Gastroesophageal Reflux Disease (GERD): The patient's vomiting and sharp chest pain could be related to GERD, especially if she has been experiencing stress or eating spicy foods.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Myocardial Infarction (MI): Although the patient is young and has no significant family history of heart disease, MI is a possibility, especially given her history of drug abuse, which can increase the risk of cardiovascular disease.
    • Aortic Dissection: This is a rare but life-threatening condition that can cause severe chest pain and shortness of breath. The patient's history of drug abuse increases her risk for cardiovascular disease, which can increase the risk of aortic dissection.
    • Pulmonary Hypertension: This condition can cause chest pain, shortness of breath, and vomiting, and is more common in individuals with a history of drug abuse.
  • Rare diagnoses
    • Spontaneous Hemopneumothorax: This is a rare condition that can cause sharp chest pain and shortness of breath, and is more common in young women.
    • Catamenial Pneumothorax: This is a rare condition that occurs in women, where air enters the pleural space during menstruation, causing sharp chest pain and shortness of breath.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.