From the Research
For individuals taking Mounjaro (tirzepatide), a comprehensive digestive enzyme supplement containing amylase, protease, and lipase would be most beneficial to mitigate potential digestive side effects. The most recent and highest quality study 1 suggests that tirzepatide has hepatoprotective effects, which may be beneficial for individuals with metabolic dysfunction-associated fatty liver disease. However, the primary concern for individuals taking Mounjaro is the potential for digestive side effects such as nausea, bloating, or constipation due to its mechanism of slowing gastric emptying. Some key points to consider when selecting a digestive enzyme supplement include:
- The supplement should contain a combination of amylase, protease, and lipase to help break down proteins, carbohydrates, and fats.
- Products like Enzymedica Digest Gold or Pure Encapsulations Digestive Enzymes Ultra are good options to consider.
- It is essential to consult with a healthcare provider before adding any supplement to the regimen, especially when taking prescription medications like Mounjaro, to ensure there are no potential interactions or contraindications for the specific health situation. Additionally, a study from 2 found that tirzepatide had identical risks of pancreatitis to placebo, which is reassuring for individuals taking this medication. Overall, while the evidence suggests that tirzepatide is generally safe and effective, individuals taking Mounjaro should prioritize their digestive health and consider a comprehensive digestive enzyme supplement to mitigate potential side effects.