From the Research
Zepbound (tirzepatide) can cause several neurologic side effects, including headache, dizziness, and fatigue, with the most recent and highest quality study 1 not specifically reporting on neurologic side effects, but previous studies 2, 3, 4, 5 indicating that these effects are generally mild to moderate and may diminish over time.
Common Neurologic Side Effects
- Headache
- Dizziness
- Fatigue
- Paresthesia (tingling sensations)
- Changes in taste perception
Serious but Rare Neurologic Effects
- Hypoglycemia, which can lead to confusion, weakness, or even loss of consciousness if severe
- Attention difficulties and memory issues in some patients
Management of Neurologic Side Effects
If you experience persistent or severe neurologic symptoms while taking Zepbound, contact your healthcare provider immediately. The neurologic effects are believed to be related to the medication's impact on GLP-1 and GIP receptors in the brain, as these hormones have effects beyond just regulating blood glucose and can influence neural function. Starting with the lowest dose and gradually increasing as tolerated may help minimize these side effects. It is essential to weigh the benefits of Zepbound in improving glycemic control and weight loss against the potential risks of neurologic side effects, prioritizing morbidity, mortality, and quality of life as the primary outcomes 1.