What cardiac disease is associated with macroglossia (enlarged tongue)?

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Last updated: February 19, 2025View editorial policy

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Differential Diagnosis for Cardiac Disease with Swollen Tongue

  • Single most likely diagnosis
    • Heart failure: This condition can lead to fluid buildup in the body, causing swelling in various parts, including the tongue. The swollen tongue can be a sign of congestive heart failure, particularly in patients with a history of cardiac disease.
  • Other Likely diagnoses
    • Hypertrophic cardiomyopathy: This condition can cause heart failure, leading to fluid buildup and swelling. Although less common, it is a possible cause of a swollen tongue in the context of cardiac disease.
    • Cardiac amyloidosis: Amyloid deposits can accumulate in the heart, leading to heart failure and fluid buildup, which may cause a swollen tongue.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cardiac tamponade: Although rare, cardiac tamponade can cause heart failure and fluid buildup, leading to a swollen tongue. Missing this diagnosis can be fatal, as it requires immediate medical attention.
    • Constrictive pericarditis: This condition can cause heart failure and fluid buildup, leading to swelling, including a swollen tongue. It is essential to consider this diagnosis to provide timely and appropriate treatment.
  • Rare diagnoses
    • Fabry disease: This rare genetic disorder can cause cardiac disease and lead to fluid buildup, resulting in a swollen tongue. Although uncommon, it is essential to consider this diagnosis in patients with unexplained cardiac disease and swelling.
    • Transthyretin amyloidosis: This rare condition can cause cardiac disease and lead to fluid buildup, resulting in a swollen tongue. It is crucial to consider this diagnosis in patients with unexplained cardiac disease and swelling, particularly those with a family history of the condition.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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