What is the dosage of Meclizine (Antivert)?

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Last updated: May 8, 2025 • View editorial policy

From the Research

Vertin, also known as betahistine, is typically prescribed for vertigo and Meniere's disease at a dosage of 72-864 mg/day, with a mean dosage of 204.9 mg/day, as evidenced by a study that combined betahistine with the MAO-B inhibitor selegiline 1.

Key Points to Consider

  • The dosage of betahistine can be reduced to about one tenth when combined with selegiline, an MAO-B inhibitor, to achieve the same treatment response 1.
  • The initial dosage for the long-term "titration" of the attacks of vertigo was 9-80 24-mg tablets/day, i.e., 216-1920 mg/day, but was reduced to 3-36 24-mg tablets, i.e., 72-864 mg/day, after combination with selegiline 1.
  • Betahistine works by improving blood flow in the inner ear and regulating histamine activity, which helps reduce vertigo symptoms 2.
  • Treatment duration varies depending on symptom improvement, but often continues for several months, with some patients requiring long-term therapy.
  • Betahistine is generally well-tolerated, though some patients may experience mild side effects like headache, nausea, or indigestion.

Important Considerations

  • If symptoms don't improve after 2-3 weeks of treatment, or if side effects are troublesome, patients should consult their healthcare provider for possible dosage adjustment or alternative treatment options.
  • The combination of betahistine with selegiline may be an alternative to high-dosage monotherapy with betahistine for Meniere's disease, as it can achieve the same clinical effect with a significantly lower dosage of betahistine 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.