From the Guidelines
The recommended dosage for Cozaar (losartan potassium) is 25-50 mg daily, with a goal dose of 25-100 mg daily in 1-2 divided doses, as supported by the most recent and highest quality study 1.
Key Considerations
- The starting dose for Cozaar can be 25-50 mg once daily for adults with hypertension, which can be increased to a maximum of 100 mg daily if needed for blood pressure control.
- For patients with specific conditions such as heart failure, left ventricular hypertrophy, or diabetic nephropathy, the recommended dose may vary, but the goal remains to achieve optimal blood pressure control while minimizing side effects.
- Elderly patients or those with hepatic impairment may require lower starting doses, typically 25 mg daily, to avoid adverse effects.
Mechanism and Administration
- Cozaar works by blocking angiotensin II receptors, which helps to relax blood vessels and lower blood pressure.
- It can be taken at the same time each day, with or without food, to maintain consistent blood levels.
- Patients should not discontinue Cozaar without consulting their healthcare provider, as sudden discontinuation can lead to rebound hypertension or worsening of underlying conditions.
Evidence-Based Recommendations
- The dosage recommendations are based on the latest guidelines and studies, including the 2007 KDOQI clinical practice guidelines 1 and the 2022 AHA/ACC/HFSA guideline for the management of heart failure 1.
- These guidelines emphasize the importance of achieving goal blood pressure levels to reduce the risk of morbidity and mortality associated with hypertension and related conditions.
- By following the recommended dosage and administration guidelines for Cozaar, healthcare providers can help patients achieve optimal blood pressure control and improve their overall quality of life.
From the FDA Drug Label
The usual starting dose of losartan is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy). The usual starting dose is 50 mg of losartan once daily. The dose should be increased to 100 mg once daily based on blood pressure response In patients with mild-to-moderate hepatic impairment the recommended starting dose of losartan is 25 mg once daily.
The dose of Cozar (Losartan) is:
- Starting dose: 50 mg once daily
- Maximum dose: 100 mg once daily
- Starting dose for patients with possible intravascular depletion: 25 mg once daily
- Starting dose for patients with mild-to-moderate hepatic impairment: 25 mg once daily 2
From the Research
Cozar Dose Information
- The term "Cozar" is another name for the medication losartan, which is often used in combination with hydrochlorothiazide (HCTZ) to treat hypertension and other conditions 3, 4, 5, 6, 7.
- The typical dose of losartan in combination with HCTZ can vary, but common doses include losartan 50 mg and HCTZ 12.5 mg 3, 6, 7.
- In some cases, the dose of losartan may be increased to 100 mg, either alone or in combination with HCTZ 3, 7.
- The choice of dose and combination therapy may depend on the individual patient's condition, including the presence of diabetes, hyperuricemia, or impaired renal function 3, 6.
Factors Influencing Cozar Dose
- The presence of diabetes may influence the choice of dose and combination therapy, with some studies suggesting that a maximum dose of losartan may be more beneficial in patients with hyperuricemia and impaired renal function 3.
- The combination of losartan and HCTZ may be a useful option in hypertensive patients with diabetes, provided that metabolic parameters are closely monitored 3, 6.
- The safety and efficacy of losartan/HCTZ combination therapy have been established in various patient populations, including Very-Elderly patients 7.