From the Research
Anastrozole is a viable treatment option for men with conditions related to excess estrogen or hormonal imbalances, and its use should be considered on a case-by-case basis, prioritizing the most recent and highest quality evidence available, such as the study published in 2021 1.
Key Points to Consider
- Anastrozole works by inhibiting the aromatase enzyme, which converts testosterone to estrogen, thereby reducing estrogen levels in the body.
- The typical dose ranges from 0.5 to 1 mg daily, though lower doses of 0.25 to 0.5 mg taken 2-3 times weekly may be used for certain conditions.
- Men primarily use anastrozole to treat gynecomastia (enlarged breast tissue), to manage estrogen-related side effects from testosterone replacement therapy, or in cases of male infertility related to hormonal imbalances.
- Side effects may include joint pain, decreased bone density with long-term use, fatigue, and mood changes.
- Men taking anastrozole should have regular blood tests to monitor hormone levels and liver function.
Recent Evidence
- A 2021 study published in Translational Andrology and Urology found that anastrozole improves hormonal profiles and semen parameters in hypogonadal, subfertile men with body mass index over 25 kg/m2 and may aid in achieving pregnancy, especially in conjunction with assisted reproductive techniques 1.
- Another study published in 2021 in Human Reproduction Update summarized the clinical trials and relevant basic research on the application of aromatase inhibitors, including anastrozole, in the treatment of male infertility, highlighting their potential benefits and side effects 2.
Clinical Application
- Anastrozole should only be taken under medical supervision, as improper use can lead to hormonal imbalances that may cause additional health problems.
- Treatment duration varies based on the condition being treated, ranging from several months for gynecomastia to ongoing use for those on testosterone therapy.
- The medication's efficacy and safety profile, as well as its potential benefits and risks, should be carefully considered and monitored in each individual case.