What are the causes of a swollen Parotid (salivary) gland?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 8, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Swollen Parotid Gland

  • Single Most Likely Diagnosis
    • Viral parotitis (mumps): This is the most common cause of swollen parotid glands, especially in children and young adults, due to its high prevalence and contagious nature.
  • Other Likely Diagnoses
    • Bacterial parotitis: This condition, often caused by Staphylococcus aureus, can lead to a swollen parotid gland, especially in the context of dehydration, poor oral hygiene, or recent surgery.
    • Sialadenitis: Inflammation of the salivary gland, which can be caused by a variety of factors including infection, obstruction, or autoimmune disorders.
    • Sjögren's syndrome: An autoimmune disorder that can cause inflammation and swelling of the parotid glands, among other symptoms.
  • Do Not Miss Diagnoses
    • Parotid gland tumor (benign or malignant): Although less common, tumors of the parotid gland can cause swelling and must be considered to avoid delayed diagnosis of a potentially life-threatening condition.
    • Sarcoidosis: A systemic disease that can cause inflammation and swelling in various parts of the body, including the parotid glands, and requires prompt diagnosis and treatment.
  • Rare Diagnoses
    • Heerfordt's syndrome (uveoparotid fever): A rare form of sarcoidosis that affects the parotid gland, eyes, and sometimes the central nervous system.
    • IgG4-related disease: A rare autoimmune disorder that can cause inflammation and swelling in various organs, including the parotid glands.
    • Parotid gland abscess: A rare but serious condition that requires immediate medical attention to prevent complications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.