From the Guidelines
Taking Mydayis with high-fat meals can prolong its effect, as fatty foods slow gastric emptying and drug absorption, thereby extending the duration of action of this extended-release stimulant medication. Several factors can influence the duration of action of Mydayis, an extended-release stimulant medication containing mixed amphetamine salts used to treat ADHD.
- Factors that can prolong the effect of Mydayis include:
- Taking the medication with high-fat meals, as this slows gastric emptying and drug absorption, extending the duration of action 1.
- Certain medications, particularly those that inhibit CYP2D6 enzymes, may prolong Mydayis's effects by slowing its metabolism.
- Individuals with liver or kidney impairment naturally process the medication more slowly, leading to extended effects.
- Genetic variations affecting drug metabolism can also cause some people to break down amphetamines more slowly. It's essential to note that intentionally prolonging Mydayis's effects beyond prescribed parameters may increase side effect risks and should only be done under medical supervision, as stimulant medications are associated with a range of adverse effects, including decreased appetite, sleep disturbances, and increased blood pressure and pulse 1. If the medication isn't lasting long enough, discussing dosage adjustments with your healthcare provider is the appropriate approach rather than attempting to manipulate its duration yourself.
From the Research
Prolonging the Effect of Mydayis
To prolong the effect of Mydayis, which is a medication used to treat Attention Deficit Hyperactivity Disorder (ADHD), several factors can be considered:
- Dosage and formulation: The choice of drug formulation, such as immediate-release or modified-release, can impact the duration of action 2.
- Individual factors: Body weight is a fundamental determinant of differences in observed amphetamine plasma concentrations, which may affect the duration of action 2.
- Combination with other treatments: Non-pharmacological treatments, such as psychoeducation and environmental modifications, may enhance the effectiveness of Mydayis and potentially prolong its effect 3.
- Titration and adjustment: The dosage of Mydayis can be tailored to individual patients' circumstances and titrated week by week, according to response 3.
Amphetamine Formulations and Duration of Action
Different amphetamine formulations may have varying durations of action:
- Immediate-release formulations: Typically provide a shorter duration of action, with a Tmax from 2 to 3 hours 2.
- Modified-release formulations: May provide a longer duration of action, with flexibility in dosing and drug onset and offset 2.
- Lisdexamfetamine: Has been shown to reduce the severity of ADHD symptoms, with a duration of action that may be longer than other amphetamine formulations 4.
Safety and Efficacy Considerations
When considering ways to prolong the effect of Mydayis, it is essential to weigh the potential benefits against the risks: