From the Research
Elevated serum creatinine levels are associated with cognitive impairment, and monitoring creatinine levels is crucial for early detection and management of chronic kidney disease (CKD) to prevent cognitive decline. The relationship between serum creatinine and cognitive function is complex, and several studies have investigated this association. A study published in 2009 1 found that non-dialysis-dependent CKD is related to cognitive impairment, and the associations of CKD with cognition were not eliminated by statistical control for cardiovascular disease correlates of CKD.
The study highlighted the importance of considering serum creatinine levels in the assessment of cognitive function, particularly in individuals with CKD. Another study published in 2021 2 discussed the limitations of estimating glomerular filtration rate (GFR) using serum creatinine and emphasized the need for direct measurement of GFR using an exogenous marker such as iohexol in certain clinical scenarios.
However, the most recent and highest-quality study on this topic is not directly related to the question of creatinine and cognitive function. Therefore, based on the available evidence, monitoring serum creatinine levels and maintaining optimal kidney function through lifestyle modifications and medical treatment can help prevent cognitive decline. It is essential to note that the relationship between serum creatinine and cognitive function is influenced by various factors, including age, sex, muscle mass, and body composition, and should be interpreted in the context of individual patient characteristics.
Some studies have also investigated the effects of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) on kidney function and cognitive outcomes in patients with CKD 3, 4. While these studies provide valuable insights into the management of CKD, they do not directly address the question of creatinine and cognitive function.
In summary, elevated serum creatinine levels are associated with cognitive impairment, and monitoring creatinine levels is crucial for early detection and management of CKD to prevent cognitive decline. Healthcare providers should consider serum creatinine levels in the assessment of cognitive function, particularly in individuals with CKD, and develop personalized treatment plans to maintain optimal kidney function and prevent cognitive decline.