From the Guidelines
Lanreotide can potentially cause mood swings and anxiety as side effects, though they are not among the most commonly reported reactions. The use of somatostatin analogues like lanreotide is well-established in the management of gastroenteropancreatic neuroendocrine tumors (NETs), with studies such as the one published in Gut in 2012 1 highlighting their efficacy in symptomatic control and improvement in quality of life (QoL) for patients with NETs. While the primary focus of such studies is on the biochemical response rates and symptomatic control, the potential for neuropsychiatric effects, including mood swings and anxiety, should not be overlooked.
The mechanism of action of lanreotide, which involves binding to somatostatin receptor subtypes and inhibiting the release of various peptide hormones, could theoretically influence mood regulation, given the complex interplay between hormonal balances and psychological states. However, detailed discussions on specific side effects like mood swings and anxiety are not prominently featured in the provided evidence, suggesting that these may not be as commonly encountered or as prominently studied as other side effects like gastrointestinal issues or injection site reactions.
Given the potential for lanreotide to impact mood, it is crucial for patients experiencing persistent or severe mood swings or anxiety while on lanreotide to consult their healthcare provider. The provider can assess whether these symptoms are likely related to the medication and adjust the treatment plan as necessary, considering the balance between the benefits of lanreotide in managing NETs and the potential for adverse effects on mental health. This approach prioritizes both the effective management of the underlying condition and the patient's overall quality of life, including their mental well-being.
From the Research
Lanreotide and Mood Swings or Anxiety
- There is no direct evidence in the provided studies that lanreotide causes mood swings or anxiety 2, 3, 4.
- The studies primarily focus on the use of lanreotide in treating conditions such as congenital hyperinsulinism 2, neuroendocrine tumors 3, and carcinoid syndrome 4, without mentioning its effects on mood or anxiety.
- However, it is worth noting that somatostatin analogs like lanreotide can have various side effects, but the provided studies do not specifically address mood swings or anxiety as potential side effects 2, 3, 4.
- Studies on depression and anxiety treatment do not mention lanreotide as a potential cause of mood swings or anxiety 5, 6.
- Further research would be needed to determine if lanreotide has any impact on mood or anxiety, as the current evidence does not provide a clear answer 2, 5, 6, 3, 4.