From the FDA Drug Label
HYDROQUINONE USP, 4% SKIN BLEACHING CREAM should be applied to affected areas and rubbed in well twice daily, in the morning and before bedtime, or as directed by a physician. The application instructions for Pigmanorm (which is another name for hydroquinone) are to apply the cream to affected areas and rub it in well, twice daily (in the morning and before bedtime), or as directed by a physician 1.
- Apply to affected areas
- Rub in well
- Twice daily
- In the morning and before bedtime
- Or as directed by a physician.
From the Research
To apply Pigmanorm for patients, first wash and dry the affected skin area thoroughly, then apply a thin layer of the cream only to the darkened areas, avoiding surrounding normal skin, and start with once-daily application, typically in the evening. Pigmanorm is a topical cream used to treat hyperpigmentation conditions like melasma, age spots, and post-inflammatory hyperpigmentation. Using clean fingertips or a cotton swab, apply the cream as directed. After application, wash your hands thoroughly. During treatment, use a broad-spectrum sunscreen (SPF 30+) daily and avoid prolonged sun exposure, as UV radiation can worsen pigmentation and reduce treatment effectiveness, as noted in a study on melasma treatment 2. Most patients see improvement within 4-8 weeks, but treatment may continue for 2-3 months depending on the condition. If skin irritation occurs, reduce application frequency to every other day or consult your healthcare provider. Pigmanorm works through its combination of hydroquinone (which inhibits melanin production), tretinoin (which increases cell turnover), and a mild corticosteroid (which reduces inflammation), making it effective for various pigmentation disorders, as discussed in a review of hyperpigmentation management 3. It's also important to consider the elimination of risk factors and strict protection against ultraviolet radiation as part of the treatment plan, as highlighted in a narrative review on melasma treatment 4. The treatment approach may include topical application of various substances, chemical peels, laser and light treatments, and/or systemic therapy, but the most effective treatment remains the use of topical agents like Pigmanorm, as supported by evidence from a study on melasma treatment 2. In terms of specific application instructions, it's crucial to follow the recommended guidelines to minimize the risk of adverse effects and maximize the efficacy of the treatment, as noted in a study on the treatment of melasma with topical agents, peels, and lasers 5. Overall, the application of Pigmanorm should be tailored to the individual patient's needs and monitored closely to ensure optimal treatment outcomes, as emphasized in a review of melasma treatment 2.