How Long Does a Tymlos Pen Last?
A single Tymlos (abaloparatide) pen lasts exactly 30 days when used as prescribed, delivering one 80 mcg dose per day. 1
Pen Duration and Usage
Each Tymlos pen is a pre-assembled, single-patient-use disposable device containing 3120 mcg of abaloparatide in 1.56 mL solution (2000 mcg/mL). The pen is calibrated to deliver 30 individual doses of 80 mcg each in 40 mcL per injection 1.
After 30 days of use, you must discard the Tymlos pen even if solution remains inside 1. This is a critical safety requirement—do not attempt to continue using the pen beyond this timeframe.
Storage Requirements
The storage instructions differ before and after first use:
- Before first use: Store refrigerated at 36°F to 46°F (2°C to 8°C) 1
- After first use: Store at room temperature 68°F to 77°F (20°C to 25°C) for up to 30 days 1
Important caveat: Unlike teriparatide, abaloparatide does not require refrigeration after the first use, which offers practical convenience 2. However, never freeze the pen or expose it to heat 1.
Treatment Duration Context
While each pen lasts 30 days, the total treatment duration with Tymlos is limited to no more than 2 years over your lifetime 2, 1. This lifetime limitation applies to both abaloparatide and teriparatide due to the boxed warning regarding osteosarcoma risk observed in animal studies 2.
After completing Tymlos therapy, you must transition to antiresorptive therapy (bisphosphonates or denosumab) to maintain bone density gains and prevent rapid bone loss 2, 3. There is no need for a "washout period" between stopping Tymlos and starting antiresorptive treatment 2.