From the Guidelines
Methamphetamine is a highly addictive and dangerous controlled substance, and any amount of illicit use is problematic and potentially harmful. The use of methamphetamine has been associated with increased stroke risk, as well as other cardiovascular problems, according to a 2024 guideline from the American Heart Association/American Stroke Association 1. This guideline highlights the dose-dependent response of heavy alcohol use and the increased risk of stroke associated with more frequent than once-weekly cannabis use. Additionally, meta-analyses have identified stroke as associated with opioid misuse, and a systematic review has found increased stroke risk with the misuse of prescription and other amphetamine-type stimulants.
The effects of methamphetamine on the cardiovascular system are similar to those of cocaine, and can precipitate acute coronary syndromes (ACS) due to increased blood pressure, heart rate, endothelial dysfunction, and platelet aggregation 1. Long-term use of methamphetamine has been associated with myocarditis, necrotizing vasculitis, pulmonary hypertension, and cardiomyopathy. The treatment of patients with ACS associated with methamphetamine use should be similar to that of patients with cocaine use, with the exception of avoiding beta blockers in patients with signs of acute intoxication.
It is essential to note that drug addiction is a chronic, relapsing condition associated with societal and health-related problems, and the use of drugs such as methamphetamine can produce acute severe blood pressure elevations, cerebral vasospasm, vasculitis, embolization, and endothelial dysfunction 1. The risk of stroke and death is increased with the use of these drugs, and long-term treatment strategies, including medication, psychological counseling, and community-based programs, are effective in the management of drug dependency.
In terms of prescribed medication, if you are referring to methylphenidate (sometimes abbreviated as "meth" in medical contexts) for conditions like ADHD, appropriate dosages vary by individual and should only be determined by a healthcare provider based on specific medical needs. Medication dosages are personalized based on factors including age, weight, medical history, and response to treatment. If you have questions about prescribed medication, please consult your healthcare provider for guidance specific to your situation.
From the Research
Definition of a Lot of Meth
The amount of methamphetamine that is considered a lot can vary depending on several factors, including the individual's tolerance, the method of use, and the duration of use. However, there is no specific quantity that is universally agreed upon as a lot of meth.
Health Risks Associated with Meth Use
- Methamphetamine use is associated with a range of physical and mental health harms, including overdose, mortality, and long-term health consequences such as cardiovascular disease, psychosis, and neurotoxicity 2, 3, 4.
- The use of methamphetamine can lead to increased heart rate, blood pressure, and cardiovascular stress, which can result in cardiac arrhythmias, cardiomyopathy, and myocardial infarction 3, 4.
- Methamphetamine use is also associated with neurological damage, including damage to the brain's serotonergic systems, which can lead to mood changes, psychosis, and memory impairment 3.
Quantities of Meth Associated with Health Risks
- While there is no specific quantity of methamphetamine that is considered a lot, the risk of adverse health effects increases with the amount and frequency of use 3, 5.
- Studies have shown that increasingly larger doses of methamphetamine are required to maintain euphoria in individuals who have developed tolerance to the drug, which can increase the risk of overdose and other adverse health effects 3.
Treatment and Prevention
- Treatment for methamphetamine dependence typically involves a combination of behavioral therapy and medication, such as bupropion, which has been shown to be effective in increasing weeks of abstinence in individuals with low-to-moderate methamphetamine dependence 6.
- Prevention and harm reduction strategies, such as community-based programs and health system initiatives, are also important for reducing the risks associated with methamphetamine use 5.