From the FDA Drug Label
The dosage information for fluticasone salmeterol is as follows: Fluticasone Propionate and Salmeterol Inhalation Powder 100 mcg/50 mcg, Fluticasone Propionate and Salmeterol Inhalation Powder 250 mcg/50 mcg, Fluticasone Propionate and Salmeterol Inhalation Powder 500 mcg/50 mcg.
The recommended dosage for fluticasone salmeterol is:
From the Research
The recommended dosage for fluticasone/salmeterol is typically 100/50,250/50, or 500/50 mcg taken as one inhalation twice daily, approximately 12 hours apart, for asthma in adults, and 250/50 mcg taken as one inhalation twice daily for COPD, as supported by the most recent study 2.
Key Considerations
- The dosage may vary depending on the specific formulation and the condition being treated, with Breo Ellipta, containing fluticasone furoate/vilanterol, generally taken as one inhalation (100/25 or 200/25 mcg) once daily 2.
- It is essential to rinse the mouth with water after each use without swallowing to prevent oral thrush, a common side effect.
- The medication should be used regularly as prescribed, even when symptoms improve, as it works by reducing inflammation and relaxing airway muscles over time.
- Fluticasone is a corticosteroid that reduces inflammation, while salmeterol is a long-acting beta-agonist that helps keep airways open.
- The doctor may adjust the dosage based on the patient's specific condition, age, and response to treatment.
Comparison of Formulations
- Studies have compared the efficacy and safety of different formulations, including UMEC/VI and FP/SAL, with results showing statistically significant improvements in lung function measures with UMEC/VI versus FP/SAL 3.
- However, the most recent and highest-quality study 2 supports the use of fluticasone/salmeterol 100/50,250/50, or 500/50 mcg taken as one inhalation twice daily for asthma in adults, and 250/50 mcg taken as one inhalation twice daily for COPD.
Safety and Efficacy
- The safety profiles of different formulations, including FP/SAL and UMEC/VI, have been shown to be similar, with adverse event rates ranging from 26 to 31% 3.
- The efficacy of fluticasone/salmeterol in improving lung function, dyspnea, and quality of life has been consistently demonstrated across various studies 4, 5, 2, 3.