From the Guidelines
The recommended dosage for fluticasone/salmeterol in adults is inhalation twice daily, with the dose depending on the level of severity or control of the condition, as stated in the expert panel report 3 (epr-3) guidelines for the diagnosis and management of asthma-summary report 2007 1. The typical adult dosage for fluticasone/salmeterol depends on the specific formulation and the condition being treated.
- For asthma, the dosage is not explicitly stated in the provided evidence, but it is mentioned that the dose depends on the level of severity or control.
- The medication should be used in conjunction with an inhaled corticosteroid (ICS), as salmeterol is a long-acting beta-agonist (LABA) that should not be used for acute symptom relief or exacerbations. Some key points to consider when prescribing fluticasone/salmeterol include:
- The medication should be taken approximately 12 hours apart.
- Patients should rinse their mouth with water after each use to prevent thrush.
- It's essential to use this medication regularly as prescribed, even when symptoms improve, as it works by reducing inflammation and relaxing airway muscles over time.
- Fluticasone is a corticosteroid that reduces inflammation in the airways, while salmeterol is a long-acting beta-agonist that helps keep airways open by relaxing the surrounding muscles.
- The combination of fluticasone and salmeterol provides both immediate and long-term control of respiratory symptoms, as supported by the guidelines for the diagnosis and management of asthma-summary report 2007 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Dosage Information
- The recommended dosage for fluticasone salmeterol in adults is not explicitly stated in the provided studies, but the studies mention various dosages used in the trials, such as 50/250 microg twice daily 2, 3 and 55/14,113/14, and 232/14 μg 4.
- A study compared the efficacy and safety of combined salmeterol fluticasone therapy (50/250 microg twice daily) with twice the dose of fluticasone propionate (500 microg twice daily) in symptomatic asthmatics, and found that the combination therapy was superior to doubling the dose of fluticasone propionate 2.
- Another study found that salmeterol/fluticasone propionate (50/250 microg) combination therapy was more effective than budesonide 800 microg twice daily in treating moderate to severe asthma 3.
Efficacy and Safety
- The combination of salmeterol and fluticasone propionate has been shown to be effective in improving lung function and symptoms in patients with asthma 2, 5, 4, 3.
- The safety profile of salmeterol/fluticasone propionate has been evaluated in several studies, and it has been found to be well-tolerated with a similar adverse event profile to fluticasone propionate alone 2, 6.
- A large clinical trial found that the risk of serious asthma-related events was not significantly higher in patients receiving salmeterol in a fixed-dose combination with fluticasone compared to those receiving fluticasone alone 6.