From the Guidelines
Fluphenazine is available under the brand names Prolixin, Permitil, and Modecate. According to the evidence provided 1, Prolixin is mentioned as a brand name for fluphenazine, alongside other typical antipsychotic agents such as Haloperidol and Thiothixene. The medication is used to treat schizophrenia and other psychotic disorders, and comes in several formulations including oral tablets, oral concentrate, and long-acting injectable forms (fluphenazine decanoate).
The use of long-acting injectable antipsychotics, such as fluphenazine decanoate, is supported by guidelines as a treatment option for patients who express a preference for such treatment due to its convenience or to avoid covert nonadherence to the antipsychotic regimen 1. The guidelines also suggest considering long-acting injection antipsychotic medication for patients with recurrent relapses related to partial or full nonadherence.
Some key points to consider when prescribing fluphenazine include:
- The medication works by blocking dopamine receptors in the brain, particularly D2 receptors, which helps reduce psychotic symptoms such as hallucinations, delusions, and disorganized thinking.
- Like other typical antipsychotics, fluphenazine carries a risk of extrapyramidal side effects including akathisia, parkinsonism, and tardive dyskinesia.
- The injectable form of fluphenazine is particularly useful for patients with adherence difficulties, as it can be administered every 2-4 weeks.
It is essential to weigh the benefits and risks of fluphenazine and other typical antipsychotics when making treatment decisions, considering the potential for significant side effects involving the cholinergic, cardiovascular, and extrapyramidal systems, as well as the inherent risk of irreversible tardive dyskinesia 1.
From the FDA Drug Label
DESCRIPTION Fluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative intended for the management of schizophrenia. DESCRIPTION Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative.
The brand name of fluphenazine is not mentioned in the provided drug labels.
- Key words: fluphenazine, brand name
- The FDA drug label does not provide information on the brand name of fluphenazine 2 3.
From the Research
Brand Name of Fluphenazine
- The brand name of fluphenazine is Prolixin, as mentioned in several studies 4, 5, 6.
- Prolixin is a potent phenothiazine-based dopamine receptor antagonist, first introduced into clinical practice in the late 1950s as a novel antipsychotic 4.
- Fluphenazine, under the brand name Prolixin, has been compared to other antipsychotics in various studies, including those on pharmacokinetics 5, 6 and efficacy 7, 8.