What is the possible diagnosis for a male patient with a normal physical examination, normal hemoglobin (Hb) levels, normal platelet count, leukocytosis with lymphocytosis, and clonal proliferation of B lymphocytes?

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Diferencial de Diagnóstico

  • Diagnóstico más probable:
    • Linfocitosis B monoclonal: La presencia de una proliferación clonal de linfocitos B en un paciente con leucocitos 12.000 y predominio de linfocitos sugiere una linfocitosis B monoclonal, que es un trastorno caracterizado por la expansión clonal de linfocitos B.
  • Otros diagnósticos probables:
    • LLC sin criterios para tratamiento: La leucemia linfocítica crónica (LLC) es un tipo de cáncer que afecta a los linfocitos B. Aunque el paciente no presenta adenomegalias ni otros síntomas, la LLC puede ser asintomática en sus etapas iniciales.
    • Linfocitosis por estrés: El estrés puede causar un aumento en el recuento de linfocitos, lo que podría explicar la leucocitosis con predominio de linfocitos en este paciente.
  • No debes perder de vista (diagnósticos potencialmente mortales):
    • LLC con necesidad de tratamiento: Aunque el paciente no presenta síntomas, es importante considerar la posibilidad de que la LLC esté en una etapa avanzada y requiera tratamiento inmediato.
  • Diagnósticos raros:
    • Otras neoplasias linfoproliferativas: Existen otras neoplasias linfoproliferativas, como la linfoma de células B, que podrían presentarse con una proliferación clonal de linfocitos B. Sin embargo, estas condiciones son menos comunes y requerirían una evaluación más detallada para ser consideradas.

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