Yes, it is completely safe to take Macrobid (nitrofurantoin) with your evening Crestor (rosuvastatin) dose.
There is no drug-drug interaction between nitrofurantoin and rosuvastatin, and you can take them together without concern.
Why This Combination is Safe
After reviewing the FDA drug labels for both medications and current medical literature, there is no documented interaction between these two drugs 1, 2. They work through completely different mechanisms and are metabolized by different pathways in your body:
Metabolic Pathways Don't Overlap
- Rosuvastatin is minimally metabolized by the liver's cytochrome P450 system and is primarily eliminated unchanged through the kidneys and bile 3
- Nitrofurantoin is an antibiotic that concentrates in the urine and doesn't interact with statin metabolism 2
What the FDA Labels Actually Say
The Crestor label specifically warns about waiting 2 hours after taking Crestor before using antacids containing aluminum and magnesium hydroxide 1. The Macrobid label similarly mentions avoiding antacids with magnesium trisilicate 2. Neither medication warns about interactions with each other.
Common Pitfalls to Avoid
The confusion you're experiencing likely stems from:
- Antacid interactions: Both drugs have warnings about specific antacids, but these are separate concerns unrelated to taking the two medications together
- General statin warnings: Crestor has important interactions with drugs like gemfibrozil, cyclosporine, and certain antiretrovirals 3, 4, but nitrofurantoin is not among them
Practical Guidance
- Take both medications as prescribed
- Take Macrobid with food (ideally breakfast and dinner) to improve absorption and reduce stomach upset 2
- Crestor can be taken any time of day, with or without food 1
- If you use antacids, wait at least 2 hours after taking either medication
You can confidently take your Macrobid and evening Crestor dose together or at the same time of day without any safety concerns.