From the Guidelines
Equivalent Volume of Hyaluronic Acid Powder
The equivalent volume to 200 milligrams (mg) of hyaluronic acid powder is typically 10 mL when reconstituted to a concentration of 20 mg/mL.
- To calculate this, we use the formula: Weight of powder (mg) = Volume of solvent (mL) × Concentration (mg/mL) [assuming the potency of the powder is 100% for simplicity, as specific potency values are not provided in the given evidence].
- Given that the desired weight of hyaluronic acid powder is 200 mg and assuming a common concentration of 20 mg/mL, we rearrange the formula to solve for Volume of solvent (mL): Volume of solvent (mL) = Weight of powder (mg) / Concentration (mg/mL) = 200 mg / 20 mg/mL = 10 mL, as supported by general principles of solution preparation 1.
- It's crucial to note that the actual volume may vary based on the specific product and its concentration, emphasizing the importance of following the manufacturer's guidelines for reconstitution.
- Key factors influencing the equivalent volume include the concentration of the hyaluronic acid solution and the potency of the powder, which can affect the final volume when reconstituting the powder to achieve a desired concentration.
From the Research
Volume of Hyaluronic Acid Powder
To determine the volume equivalent to 200 milligrams (mg) of hyaluronic acid powder, we need to consider the density of hyaluronic acid.
- The density of hyaluronic acid can be related to its partial specific volume, which is affected by various factors such as temperature, type of cation, cation concentration, pH, and solvent polarity 2.
- However, none of the provided studies directly report the volume equivalent to 200 mg of hyaluronic acid powder.
- Studies have focused on the analysis of hyaluronic acid concentration and molecular weight 3, determination of molecular weight by near-infrared spectroscopy 4, and comparative physical properties of hyaluronic acid dermal fillers 5.
- Another study discussed the role of clinical examination in midface volume correction using hyaluronic acid fillers, but it does not provide information on the volume of hyaluronic acid powder 6.
Available Data
- The provided studies do not offer a direct conversion from mass to volume for hyaluronic acid powder.
- Without the density or partial specific volume of hyaluronic acid under specific conditions, it is not possible to accurately calculate the volume equivalent to 200 mg of hyaluronic acid powder based on the given information 2.