What is a non-gynecological cytology test?

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Last updated: February 19, 2025View editorial policy

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From the Guidelines

A non-gynecological cytology test is a diagnostic procedure that examines cells from non-reproductive organs or tissues to detect abnormal cell growth, cancer, or other conditions.

Examples of Non-Gynecological Cytology Tests

  • Thoracentesis: a procedure that involves collecting a sample of pleural fluid to diagnose lung cancer, as recommended by the American College of Chest Physicians evidence-based clinical practice guidelines 1
  • Sputum cytology: to diagnose lung cancer
  • Fine-needle aspiration cytology: to evaluate thyroid nodules
  • Urine cytology: to detect bladder cancer These tests typically involve collecting a sample of cells from the affected area using a brush, needle, or other instrument, which is then examined under a microscope to identify any abnormal cell morphology.

Key Considerations

  • The diagnostic yield of non-gynecological cytology tests depends on various factors, including sample preparation, the experience of the cytologist, and the type of tumor 1
  • Ultrasound guidance can improve the accuracy and safety of these tests, particularly in the case of thoracentesis, by reducing the incidence of iatrogenic pneumothorax 1

From the Research

Definition of Non-Gynecological Cytology Test

A non-gynecological cytology test refers to the examination of cells from non-gynecological sites, such as the lung, thyroid, breast, lymph nodes, and other organs, to aid in the diagnosis of various diseases, including cancer [ 2, 3,4,5,6 ].

Types of Non-Gynecological Cytology Tests

Some common types of non-gynecological cytology tests include:

  • Fine needle aspiration (FNA) cytology [ 2, 4,5,6 ]
  • Liquid-based cytology (LBC) [ 2, 5,6 ]
  • Conventional smears 5, 6

Characteristics of Non-Gynecological Cytology Tests

Non-gynecological cytology tests have several characteristics, including:

  • Examination of cells from non-gynecological sites [ 2, 3,4,5,6 ]
  • Use of various techniques, such as LBC and conventional smears 5, 6
  • Importance of cellular morphology and architecture in diagnosis 4, 5, 6

Applications of Non-Gynecological Cytology Tests

Non-gynecological cytology tests have various applications, including:

  • Diagnosis of cancer 3, 4
  • Evaluation of lymph node aspirates 6
  • Examination of cells from various organs, such as the lung, thyroid, and breast [ 2, 3,4,5 ]

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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