From the Research
Elevated blood protein levels are primarily caused by chronic inflammation, oxidative stress, and kidney disease, as evidenced by recent studies 1. These conditions can lead to an overproduction of immune proteins, such as antibodies, and a reduction in the clearance of proteins from the bloodstream. Some key factors that contribute to elevated blood protein levels include:
- Dehydration, which concentrates proteins in the blood
- Infections and inflammation, which trigger the production of antibodies and other immune proteins
- Certain cancers, such as multiple myeloma, which cause overproduction of specific proteins called immunoglobulins
- Liver and kidney diseases, which reduce the clearance of proteins from the bloodstream
- Certain medications, which may contribute to elevated levels as well According to a study published in 2021 1, chronic kidney disease (CKD) is a complex condition characterized by chronic inflammation, oxidative stress, and early vascular aging, which can lead to elevated blood protein levels. Another study published in 2020 2 found that uric acid induces immune system activation and alters the characteristics of resident kidney cells, leading to a proinflammatory and profibrotic state, which can also contribute to elevated blood protein levels. Additionally, a study published in 2014 3 found that protein-bound uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, have pro-inflammatory and pro-oxidative properties and are associated with elevated levels of inflammatory markers and antioxidant enzymes in patients with stage 3-4 CKD. Therefore, it is essential to address the underlying cause of elevated blood protein levels, rather than just treating the symptoms, to improve morbidity, mortality, and quality of life 1.