What is the dose of ivermectin (antiparasitic medication) for the treatment of pediculosis (lice infestation)?

From the Guidelines

For lice treatment, oral ivermectin is typically given as a single 200 μg/kg dose, with a second dose often recommended 9 to 10 days later to kill newly hatched lice. This medication works by paralyzing and killing the lice by interfering with their nervous system 1. Ivermectin is generally reserved for cases where topical treatments have failed or aren't feasible. Before taking ivermectin, patients should inform their healthcare provider about any other medications they're taking and any medical conditions they have, as certain situations may contraindicate its use. Some key points to consider when using ivermectin for lice treatment include:

• The dosage should be determined by a healthcare provider based on the patient's weight and specific situation 1.
• Ivermectin should not be used for children who weigh less than 15 kg due to the risk of adverse drug reactions 1.
• Treatment should be accompanied by washing bedding and clothing in hot water to prevent reinfestation.
• Common side effects may include headache, dizziness, or mild skin rash. It's essential to follow the recommended dosage and treatment schedule to ensure effective treatment and minimize the risk of side effects 1.

From the Research

Dose of Ivermectin for Lice Treatment

• The dose of ivermectin for lice treatment varies across studies, but common doses include:
  • 200 μg/kg, given as a single dose or repeated after 7-10 days if necessary 2, 3
  • 400 μg/kg, given on days 1 and 8 4
• These doses have been shown to be effective in eradicating head lice infestations, with cure rates ranging from 77% to 97% 4, 2, 3
• Oral ivermectin has been compared to topical treatments such as malathion and permethrin, and has been found to be comparable or superior in effectiveness 4, 5
• The use of oral ivermectin for lice treatment is supported by several studies, which suggest that it is a promising alternative to traditional topical therapies 2, 3, 5

Efficacy and Safety

• The efficacy and safety of oral ivermectin for lice treatment have been evaluated in several clinical trials, with results indicating that it is well-tolerated and effective 4, 2, 5
• Common adverse events associated with oral ivermectin are minimal, and the treatment is generally well-perceived by patients and caretakers 4, 5
• The use of oral ivermectin for lice treatment is particularly useful in cases where traditional topical therapies have failed or are not effective 5