What are the two main systems of the body that function in regulating other systems, namely the Nervous (NS) system and the Endocrine (ES) system?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 9, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

The two main systems of the body that function in regulating other systems are the nervous system and the endocrine system. These systems work together to maintain homeostasis and coordinate bodily functions. The nervous system provides rapid, short-term control through electrical signals (action potentials) transmitted along neurons, allowing for immediate responses to stimuli. It consists of the central nervous system (brain and spinal cord) and peripheral nervous system, which connects to organs and tissues throughout the body. The endocrine system, on the other hand, provides slower but longer-lasting regulation through hormones released into the bloodstream by various glands, including the pituitary, thyroid, adrenal, and pancreas, as described in 1. These hormones act as chemical messengers that bind to specific receptors on target cells, triggering cellular responses that affect metabolism, growth, development, reproduction, and other essential functions, with their effects differing based on an individual’s stage of development, as noted in 1. Together, these two regulatory systems ensure that the body's internal environment remains stable despite changing external conditions. Some key aspects of the endocrine system include the hypothalamic pituitary axis, which consists of two separate neuroendocrine organs: the anterior pituitary system and the posterior pituitary system, as outlined in 1. The hormones of the anterior pituitary are thyroid-stimulating hormone, adrenal corticotrophic hormone, prolactin, growth hormone, and the gonadotropins, which are secreted under the influence of hypothalamic trophic factors. The posterior pituitary gland consists of axonal terminations of neurons whose cell bodies are located in the hypothalamus, and the principal hormones secreted by these cells are oxytocin and vasopressin or antidiuretic hormone. The hypothalamus also participates in complex mediation of food intake, temperature regulation, sleep and arousal, memory, thirst, and other autonomic functions, highlighting the intricate and essential role of the endocrine system in regulating various bodily functions, as discussed in 1.

From the Research

Main Systems of the Body

The two main systems of the body that function in regulating other systems are:

  • The endocrine system, which produces hormones to control various processes in the body, including growth and development, metabolism, and reproduction 2, 3
  • The nervous system, although not directly mentioned in the provided studies, is often considered the other main system that regulates other systems in the body

Endocrine System

The endocrine system is a complex system that helps maintain homeostasis in the body 2. It consists of various glands that produce hormones, including:

  • The hypothalamus, which produces releasing and inhibiting hormones that act on the pituitary gland 3
  • The pituitary gland, which produces hormones that stimulate the release of hormones from other glands 3
  • The adrenal glands, which produce cortisol 3
  • The gonads (ovaries and testes), which produce sex hormones 3
  • The thyroid, which produces thyroid hormone 3
  • The parathyroid, which produces parathyroid hormone 3
  • The pancreas, which produces insulin and glucagon 3

Regulation of Other Systems

The endocrine system plays a crucial role in regulating other systems in the body, including:

  • The metabolic system, which is regulated by hormones such as insulin and glucagon 3
  • The reproductive system, which is regulated by sex hormones 3
  • The cardiovascular system, which is affected by hormones such as cortisol 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The endocrine system and associated disorders.

British journal of nursing (Mark Allen Publishing), 2022

Research

The endocrine system: an overview.

Alcohol health and research world, 1998

Research

The human stress response.

Nature reviews. Endocrinology, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.