From the FDA Drug Label
ADVERSE REACTIONS Adverse reactions to sucralfate in clinical trials were minor and only rarely led to discontinuation of the drug. INDICATIONS AND USAGE Hyoscyamine sulfate is effective as adjunctive therapy in the treatment of peptic ulcer. It can also be used to control gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps
The FDA drug label does not answer the question.
From the Research
For abdominal cramping after eating in a person with atrial fibrillation (AFib), sucralfate is generally considered safer than hyoscyamine. Sucralfate (typically dosed at 1 gram four times daily) works by forming a protective barrier over irritated areas in the digestive tract without significant systemic absorption, making it unlikely to affect heart rhythm or interact with AFib medications 1. Hyoscyamine, an anticholinergic medication, can potentially worsen AFib by increasing heart rate and potentially causing palpitations. Additionally, hyoscyamine may interact with common AFib medications and cause side effects like dry mouth, blurred vision, and urinary retention.
Some studies have investigated the effects of atrial fibrillation ablation on gastric motility, which may be relevant to understanding the potential interactions between AFib and gastrointestinal symptoms 1. However, the most recent and highest quality study on the topic of anti-arrhythmic effects in human atria suggests that combined use of sodium blockers and acacetin may have synergistic effects without significant alterations of ventricular repolarization and QT intervals 2.
Key points to consider when using sucralfate for abdominal cramping in a person with AFib include:
- Take sucralfate on an empty stomach, 1 hour before meals and at bedtime
- Consider alternative options like simethicone for gas, dietary modifications, or proton pump inhibitors if acid-related symptoms are present
- Investigate the underlying cause of the cramping, as it could be related to irritable bowel syndrome, food intolerances, or other digestive disorders that might require specific treatment approaches. It is essential to consult with a doctor to determine the best course of treatment for abdominal cramping in a person with AFib, as individual circumstances may vary.