How does a negative graduated compression bandage, also known as a negative pressure (NP) or vacuum-assisted closure (VAC) device, work?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 10, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

A negative graduated compression bandage works by applying varying levels of pressure to the limb, with the highest pressure at the distal end and gradually decreasing pressure as it moves proximally, thereby improving venous and lymphatic return and reducing edema. This pressure gradient helps to force fluid to move from areas of higher pressure to areas of lower pressure, which in turn improves circulation and promotes healing in conditions like venous ulcers, lymphedema, and post-surgical swelling 1. The bandage is typically applied in a spiral or figure-eight pattern, starting at the toes or fingers and working upward.

Key Points to Consider

  • The compression helps reduce edema by preventing fluid accumulation in the tissues, and improves circulation, which is essential for promoting healing in various conditions 1.
  • For effective use, the bandage should be applied with consistent tension, replaced regularly, and monitored for complications such as skin irritation or circulatory compromise.
  • The physiological basis for its effectiveness lies in Starling's forces, where external pressure counteracts hydrostatic pressure that would otherwise cause fluid to leak from blood vessels into surrounding tissues.
  • A minimum pressure of 20 to 30 mm Hg is recommended, with pressures of 30 to 40 mm Hg advised for more severe disease 1.

Application and Monitoring

  • The bandage should be applied by a healthcare professional to ensure proper fitting and to provide education and detailed instructions to the patient 1.
  • Regular monitoring is necessary to assess the effectiveness of the treatment and to identify any potential complications early on.
  • The use of negative graduated compression bandages has been shown to be effective in preventing ulcer recurrence and healing ulcers, particularly in patients with venous leg ulcers 1.

From the Research

Mechanism of Negative Graduated Compression Bandage

  • A negative graduated compression bandage works by applying higher pressure over the calf than at the distal leg, which enhances venous pump function 2.
  • This type of compression bandage is more effective than traditional graduated compression in improving venous haemodynamics, especially in patients with severe venous incompetence 2.
  • The increased pressure over the calf helps to reduce venous stasis, venous hypertension, and venous edema, which are common symptoms of chronic venous insufficiency 3, 4.

Comparison with Graduated Compression

  • Graduated compression bandages, which apply higher pressure at the distal leg than at the calf, are less effective in enhancing venous pump function compared to negative graduated compression bandages 2.
  • However, graduated compression stockings with different pressure profiles can still have a positive effect on venous function, with lighter pressures being more suitable for subjects who require long-term inactive standing or sitting, and mild pressures being sufficient for most clinical applications 5.

Clinical Applications

  • Negative graduated compression bandages can be used in the management of lymphedema and chronic venous insufficiency, particularly in patients who require long-term treatment and have limited mobility 6.
  • The use of compression therapy, including negative graduated compression bandages, can help reduce swelling, improve venous return, and enhance overall quality of life for patients with these conditions 3, 4, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

High compression pressure over the calf is more effective than graduated compression in enhancing venous pump function.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2012

Research

Compression therapy for chronic venous insufficiency.

Seminars in vascular surgery, 2005

Research

Use of compression therapy in patients with lymphoedema.

Nursing standard (Royal College of Nursing (Great Britain) : 1987), 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.