From the Research
An elevated white blood cell (WBC) count with low eosinophils and lymphocytes on a complete blood count (CBC) typically indicates an acute inflammatory response, most commonly due to bacterial infection, and requires prompt evaluation and treatment to prevent complications. This pattern, known as a "left shift," occurs when your body rapidly produces neutrophils to fight infection, temporarily decreasing the relative percentages of other white blood cells like lymphocytes and eosinophils 1. You should consult with a healthcare provider promptly as this finding may require further evaluation including additional blood tests, imaging studies, or cultures to identify the underlying cause.
Possible Causes and Diagnostic Approaches
- Bacterial infections, such as pneumonia, urinary tract infections, cellulitis, or appendicitis, are common causes of this pattern and may require antibiotic treatment.
- Severe stress, trauma, or corticosteroid use can also lead to this pattern.
- The low eosinophil count (eosinopenia) specifically can be a marker of acute inflammation, while low lymphocytes (lymphopenia) may indicate the body's stress response through cortisol release 2.
- Recent studies have highlighted the role of extended white blood cell parameters, such as high fluorescence lymphocyte count (HFLC) and immature granulocyte (IG) count, in distinguishing between viral and bacterial infections 1.
Importance of Prompt Evaluation and Treatment
Without addressing the underlying cause, this imbalance in white blood cells can persist and potentially lead to complications of the primary condition. It is essential to identify the cause of the elevated WBC count and low eosinophils and lymphocytes to provide appropriate treatment and prevent long-term consequences. Prompt consultation with a healthcare provider is crucial to determine the best course of action and prevent potential complications.