From the FDA Drug Label
Store MOUNJARO in the refrigerator between 36°F to 46°F (2°C to 8°C). Store MOUNJARO in the original carton until use to protect it from light. If needed, each single-dose pen or single-dose vial can be stored at room temperature up to 86°F (30°C) for up to 21 days. Do not freeze MOUNJARO Do not use MOUNJARO if frozen. Store MOUNJARO in a refrigerator at 2°C to 8°C (36°F to 46°F). If needed, each single-dose pen or single-dose vial can be stored unrefrigerated at temperatures not to exceed 30ºC (86ºF) for up to 21 days. Do not freeze MOUNJARO. Do not use MOUNJARO if frozen. Store MOUNJARO in the original carton to protect from light
Tirzepatide storage requirements:
- The medication should be stored in a refrigerator at a temperature between 36°F to 46°F (2°C to 8°C).
- It can be stored at room temperature for up to 21 days if needed, but should not exceed 86°F (30°C).
- Do not freeze tirzepatide, and do not use it if it has been frozen.
- Store the medication in its original carton to protect it from light 1 1.
From the Research
Yes, tirzepatide (brand name Mounjaro or Zepbound) needs to be refrigerated. The medication should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) until the expiration date or until you're ready to use it. Once you've started using a pen, it can be kept at room temperature (below 86°F or 30°C) for up to 21 days, after which it should be discarded even if there's medicine remaining. Never freeze tirzepatide, as freezing can damage the medication and the delivery device. When traveling, keep the medication cool using a refrigerated travel case or insulated bag with ice packs. Refrigeration is necessary because tirzepatide is a peptide-based medication that can degrade when exposed to higher temperatures, which would reduce its effectiveness. The active ingredients can break down over time when not properly stored, potentially making the medication less potent or ineffective, as noted in studies such as 2, 3, 4, 5, and 6. However, none of these studies directly address storage requirements, but based on the general properties of peptide-based medications, refrigeration is recommended to maintain efficacy and safety. It's essential to follow proper storage and handling procedures to ensure the medication remains effective and safe to use. Some key points to consider when storing tirzepatide include:
- Store in the refrigerator at 36°F to 46°F (2°C to 8°C)
- Keep at room temperature (below 86°F or 30°C) for up to 21 days after starting use
- Discard after 21 days, even if medicine remains
- Never freeze the medication or delivery device
- Use a refrigerated travel case or insulated bag with ice packs when traveling. By following these guidelines, you can help ensure the effectiveness and safety of tirzepatide.