From the Guidelines
Tirzepatide should be stopped at least 3 half-lives before elective surgery, and its use should be individualized based on patient profile, procedure, and anaesthetic technique, as recommended by recent guidelines 1. When considering the management of tirzepatide in the peri-operative period, it is essential to weigh the benefits of continued use, such as improved glycaemic control and weight management, against the potential risks, including delayed gastric emptying and increased risk of pulmonary aspiration 1.
- The medication's effects on gastric emptying and potential for aspiration must be carefully considered, particularly in patients undergoing major surgery or those at high risk of complications 1.
- Recent studies suggest that the risk of pulmonary aspiration may be increased with the use of GLP-1 RAs, including tirzepatide, although the magnitude of this risk is still uncertain 1.
- An individualized approach to tirzepatide management in the peri-operative period is recommended, taking into account factors such as the patient's medical history, the type of surgery, and the anaesthetic technique used 1.
- Patients should discuss the timing of tirzepatide cessation and resumption with their prescribing physician and surgeon to determine the best approach for their specific situation, and to minimize potential complications and ensure optimal outcomes 1.
From the Research
Tirzepatide and Surgery
There is no direct evidence in the provided studies regarding the relationship between tirzepatide and surgery.
Available Information on Tirzepatide
- The studies provided focus on the efficacy and safety of tirzepatide in patients with type 2 diabetes, comparing it to other treatments such as insulin glargine 2, insulin degludec 3, semaglutide 4, and placebo.
- Tirzepatide has been shown to be effective in improving glycemic control, reducing body weight, and decreasing the risk of major adverse cardiovascular events (MACE) 2, 3, 5.
- The drug has also been found to have a favorable safety profile, with a low incidence of hypoglycemia and serious adverse events 2, 5.
Potential Applications of Tirzepatide
- Tirzepatide may be a useful treatment option for patients with type 2 diabetes who are not responding to other therapies 2, 3, 5.
- The drug has also been shown to be effective in reducing body weight and improving metabolic parameters in patients with Alström syndrome, a rare genetic disorder characterized by obesity and insulin resistance 6.
- Further studies are needed to fully understand the potential benefits and risks of tirzepatide in different patient populations, including those undergoing surgery.
Key Findings
- Tirzepatide has been shown to be effective in improving glycemic control and reducing body weight in patients with type 2 diabetes 2, 3, 5.
- The drug has a favorable safety profile, with a low incidence of hypoglycemia and serious adverse events 2, 5.
- Tirzepatide may be a useful treatment option for patients with type 2 diabetes who are not responding to other therapies, as well as for patients with rare genetic disorders such as Alström syndrome 6.