From the FDA Drug Label
DIRECTIONS: Adults and children 5 to 10 drops orally, 1 time daily or as otherwise directed by a health care professional. The FDA drug label does not answer the question.
From the Research
5-HTP should be taken in the evening or before bedtime, about 30-60 minutes before sleep, to maximize its sleep-promoting effects and minimize potential daytime drowsiness, as supported by the most recent study on the topic 1. The recommended dosage ranges from 50-200 mg daily, though it is advisable to start with a lower dose and gradually increase as needed. Taking 5-HTP at night is beneficial because it helps produce serotonin, which the body then converts to melatonin, the hormone that regulates sleep. Some key points to consider when taking 5-HTP include:
- Starting with a lower dose and gradually increasing as needed
- Taking 5-HTP with food to minimize potential gastrointestinal side effects like nausea
- Consulting with a healthcare provider before starting 5-HTP, especially if taking medications for depression, migraines, or Parkinson's disease, as dangerous interactions can occur 2
- Being aware that 5-HTP may be contraindicated for depression in some patients, and its efficacy for this condition is not strongly supported by science 3 It is also important to note that while 5-HTP may have benefits for sleep quality, its effects on other conditions, such as mood support, may vary, and more research is needed to fully understand its potential benefits and risks 4.