From the Guidelines
The maximum recommended dose of Lunesta (eszopiclone) is 3 mg per day, taken immediately before bedtime 1.
Important Considerations
- It is generally recommended to start with a dose of 1 mg and increase as needed, under the guidance of a healthcare provider 1.
- The dose should not exceed 3 mg per day in non-elderly or non-debilitated patients, and 2 mg per day in elderly or debilitated patients, or those with severe hepatic impairment 1.
- Taking more than the recommended dose can increase the risk of adverse effects, such as next-day drowsiness, dizziness, and difficulty with coordination.
- It is recommended to use the lowest effective dose for the shortest duration necessary to treat insomnia 1.
Special Populations
- In elderly or debilitated patients, the recommended dose is 1 mg per day, and should not exceed 2 mg per day 1.
- In patients with severe hepatic impairment, the recommended dose is 1 mg per day, and should not exceed 2 mg per day 1.
From the FDA Drug Label
The total dose of eszopiclone tablets should not exceed 3 mg, once daily immediately before bedtime
- The maximum dose of Lunesta (eszopiclone) is 3 mg per day, for adults, taken immediately before bedtime 2.
- However, the maximum dose is lower for certain patient populations, such as:
- Geriatric or debilitated patients: 2 mg per day
- Patients with severe hepatic impairment, or taking potent CYP3A4 inhibitors: 2 mg per day
From the Research
Maximum Dose of Lunesta (Eszopiclone)
- The maximum dose of Lunesta (eszopiclone) is 3 mg for adult patients (aged 18-64 years) 3, 4, 5.
- For older adult patients (aged 65 years or older), the recommended dose is 2 mg, but it can be increased to 3 mg if necessary 4.
- The 1mg dose is recommended for sleep onset in older adult patients whose primary complaint is difficulty falling asleep 4.
- No dosage adjustment is required for patients with renal dysfunction, but patients with severe hepatic disease may require a reduced dose 3, 6.