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From the Research
Effectiveness of Artemisia against Parasites
- The effectiveness of Artemisia (black wormwood) against parasites is a topic of ongoing research, with some studies suggesting potential benefits and others indicating limitations 1, 2, 3, 4, 5.
- A study published in 2016 found that an ethanolic extract of Artemisia absinthium showed in vitro efficacy against Leishmania major, with a lethal concentration (LC50) of 101 mg/ml 2.
- However, another study published in 2021 found that Artemisia annua and artemisinins were ineffective against human Babesia microti and six Candida species 3.
- A review published in 2017 discussed the potential of artemisinin and its derivatives in treating protozoan infections beyond malaria, including Leishmania spp., Trypanosoma spp., and Toxoplasma gondii 4.
- A study published in 2012 found that dried whole plant Artemisia annua was effective as an antimalarial therapy, with a single dose reducing parasitemia more effectively than a comparable dose of pure artemisinin 5.
Key Findings
- Artemisia absinthium extract showed potential against Leishmania major, but high concentrations were required to achieve an anti-parasitic effect 2.
- Artemisia annua and artemisinins were ineffective against Babesia microti and Candida species, highlighting the importance of further research into the efficacy of these compounds against different parasites 3.
- Artemisinin and its derivatives may have potential as alternatives for treating non-malarial protozoan infections, but more studies are needed to confirm their efficacy and safety 4.
- Dried whole plant Artemisia annua may offer a cost-effective and synergistic approach to antimalarial therapy, with potential benefits for bioavailability and efficacy 5.
Parasites and Artemisia
- Leishmania major: Artemisia absinthium extract showed in vitro efficacy against this parasite, with a lethal concentration (LC50) of 101 mg/ml 2.
- Babesia microti: Artemisia annua and artemisinins were ineffective against this parasite 3.
- Candida species: Artemisia annua and artemisinins were ineffective against six species of Candida 3.
- Plasmodium chabaudi: Dried whole plant Artemisia annua reduced parasitemia more effectively than a comparable dose of pure artemisinin in a rodent malaria model 5.