What is the next step in the workup for a left submandibular swelling that is refractory to treatment with Augmentin (amoxicillin-clavulanate) and conservative measures for sialadenitis?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 10, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

For a left submandibular swelling that hasn't responded to Augmentin and conservative measures for sialadenitis, the next appropriate step is to refer the patient to oral/maxillofacial surgeons for further management, as indicated by the presence of potential salivary stones or other salivary gland disorders 1. The patient's symptoms of left submandibular swelling refractory to treatment with Augmentin and conservative measures for sialadenitis suggest the need for a more detailed evaluation. Key considerations in the workup include:

  • Advanced imaging, such as ultrasound, to visualize potential stones, ductal dilation, or abscesses in the submandibular gland, as these are common causes of pain and swelling in this area 1.
  • Laboratory tests, including complete blood count and inflammatory markers, to assess for signs of infection or inflammation.
  • Consultation with specialists, such as oral/maxillofacial surgeons, who can provide further guidance on management, including potential surgical intervention. Given the potential for salivary stones or other salivary gland disorders, as discussed in the British Journal of Anaesthesia study 1, referral to a specialist is crucial for appropriate management and to prevent potential complications. The use of broader-spectrum antibiotics, such as clindamycin or amoxicillin-clavulanate, may also be considered if there is ongoing suspicion of infection, but this should be guided by specialist advice. Ultimately, the goal is to identify the underlying cause of the swelling and develop an effective treatment plan to improve the patient's quality of life and reduce morbidity and mortality.

From the Research

Next Steps for Left Submandibular Swelling

The patient's left submandibular swelling that is refractory to treatment with Augmentin and conservative measures for sialadenitis requires further evaluation.

  • Imaging studies can be helpful in detecting the underlying cause of the swelling, such as abscesses, stones, or ductal dilation 2, 3, 4.
  • Ultrasonography (US) and computed tomography (CT) are commonly used imaging modalities for evaluating sialadenitis, with CT having a higher sensitivity and specificity than US 3.
  • Surgeon-performed ultrasound (SP-US) can also be useful in predicting sialendoscopic findings and outcomes in patients with chronic obstructive sialadenitis 5.
  • The choice of imaging modality depends on the clinical presentation and the suspected underlying cause of the swelling, as well as considerations of reliability, side effects, accessibility, and cost 4.
  • Red flags such as suspected abscess formation, signs of respiratory obstruction, facial paresis, and fixation of a mass to underlying tissue should prompt urgent referral to head and neck surgery or a visit to the emergency department 6.

Possible Diagnostic Steps

  • Perform imaging studies such as US or CT to evaluate the left submandibular gland and detect any underlying abnormalities 2, 3, 4.
  • Consider SP-US to predict sialendoscopic findings and outcomes in patients with chronic obstructive sialadenitis 5.
  • Review the patient's history and physical examination to direct management and identify any red flags that require urgent attention 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Imaging of sialadenitis.

The neuroradiology journal, 2017

Research

Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2017

Research

Diagnostic imaging in sialadenitis.

Oral and maxillofacial surgery clinics of North America, 2009

Research

Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2017

Research

Approach to sialadenitis.

Canadian family physician Medecin de famille canadien, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.