What is the association between sunburn and Systemic Lupus Erythematosus (SLE)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Sunburn is a well-established trigger for lupus flares in people with systemic lupus erythematosus (SLE), and patients should take preventive measures to avoid sun exposure and reduce the risk of flares. According to the 2024 EULAR recommendations for the non-pharmacological management of SLE, photoprotection should be advised for the prevention of flares [ 1 ]. Ultraviolet (UV) radiation is a known triggering factor of cutaneous and systemic lupus flares, and experimental studies have shown that broad-spectrum sunscreens can prevent cutaneous lesions on photo-provocation [ 1 ].

Some key measures to prevent lupus flares triggered by sunburn include:

  • Avoiding direct sun exposure, especially during days with high UV index
  • Using physical barriers such as hats, sunglasses, and long-sleeved shirts and pants
  • Applying broad-spectrum sunscreen with regular reapplication
  • Assessing the need for vitamin D supplements when indicated [ 1 ]

It is essential for people with SLE to be aware of the potential triggers of lupus flares, including sunburn, and take proactive steps to prevent them. By following these recommendations and taking preventive measures, patients with SLE can reduce their risk of flares and improve their overall quality of life [ 1 ].

From the Research

Association with Sunburn and Lupus

  • Sunburn can exacerbate lupus symptoms, particularly cutaneous lupus erythematosus 2
  • Sun avoidance and sunscreen are important preventative measures to minimize cutaneous lupus erythematosus exacerbations 2
  • There is no direct evidence in the provided studies that discusses the association between sunburn and lupus, but it is mentioned that sun avoidance is crucial in managing cutaneous lupus erythematosus 2

Treatment of Lupus

  • The treatment of lupus typically involves a combination of topical and systemic therapies, including corticosteroids, antimalarial therapy, and immunosuppressants 2, 3, 4, 5, 6
  • Corticosteroids are a mainstay of treatment for systemic lupus erythematosus, but their use can be accompanied by adverse effects and infections 4, 6
  • Other treatments, such as epratuzumab, have been studied, but their efficacy is still unclear 3

Management of Cutaneous Lupus Erythematosus

  • Limited disease is typically managed with topical corticosteroids or calcineurin inhibitors 2
  • Antimalarial therapy is the gold standard of systemic therapy for cutaneous lupus erythematosus 2
  • Sun protection is essential in managing cutaneous lupus erythematosus, and patients should avoid sun exposure and use sunscreen regularly 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.