What causes upper extremity pain?

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Last updated: February 19, 2025View editorial policy

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From the Guidelines

Upper extremity pain is often caused by musculoskeletal issues, such as strain or injury to the muscles, tendons, or ligaments, as well as nerve compression or damage 1.

Common Causes of Upper Extremity Pain

  • Superficial vein thrombosis (SVT), which can cause pain, erythema, and tenderness in the affected arm 1
  • Musculoskeletal issues, such as tendonitis, bursitis, or strain, which can cause pain and stiffness in the arm or shoulder 1
  • Nerve compression or damage, such as carpal tunnel syndrome or ulnar nerve entrapment, which can cause numbness, tingling, and pain in the arm or hand 1
  • Poor circulation, which can cause pain, numbness, and tingling in the arm or hand, especially in individuals with peripheral artery disease 1

Treatment Options

For musculoskeletal issues, over-the-counter pain relievers like acetaminophen (650-1000 mg every 4-6 hours) or ibuprofen (200-400 mg every 4-6 hours) may be recommended 1. For SVT, symptomatic treatment involving warm compresses, nonsteroidal anti-inflammatory drugs, and elevation of the affected limb should be used as clinically indicated, and prophylactic dose anticoagulation may be recommended if there is symptomatic progression or progression on imaging 1. If the pain is severe, persistent, or accompanied by other symptoms like numbness, tingling, or weakness, it's essential to consult a healthcare provider for a proper evaluation and diagnosis. In some cases, medications like aspirin (81-100 mg daily) for antiplatelet therapy or statins for cholesterol management may be prescribed under medical supervision 1.

From the Research

Causes of Upper Extremity Pain

  • The exact causes of upper extremity pain are not explicitly stated in the provided studies, as most of them focus on leg pain or other conditions 2, 3, 4.
  • However, one study mentions a patient with upper and lower back pain, bilateral radiating arm and leg pain, and abdominal pain, which was eventually diagnosed as symptomatic cholelithiasis 3.
  • Another study discusses restless arms syndrome, a rare condition characterized by an irresistible urge to move the arms, often accompanied by unpleasant sensations 5.
  • A study on exercise training for management of peripheral arterial disease mentions arm cranking as a form of exercise that can improve cardio-respiratory fitness and reduce pain 6.

Possible Factors Contributing to Upper Extremity Pain

  • Systemic and neuromusculoskeletal pathology can contribute to upper extremity pain, as seen in the case of a patient with symptomatic cholelithiasis 3.
  • Restless arms syndrome is a rare condition that can cause upper extremity pain, and its diagnosis may be overlooked 5.
  • Exercise-related factors, such as overuse or poor training techniques, may also contribute to upper extremity pain, although this is not explicitly stated in the provided studies.

Diagnostic Considerations

  • A detailed history and thorough examination are essential in diagnosing the causes of upper extremity pain, as seen in the case of a patient with symptomatic cholelithiasis 3.
  • Clinicians should be alert for restless arms syndrome-like symptoms in patients with upper extremity pain, especially if they worsen at rest and improve with movement 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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