From the Research
The recommended berberine dose is 900-1500 mg per day, divided into 2-3 doses taken with meals, with the most common dosage being 0.9-1.5 g/d, as evidenced by the most recent and highest quality study 1.
Key Considerations
- The dosage of berberine can be adjusted based on individual tolerance and specific health conditions, such as blood sugar management.
- Berberine has a relatively short half-life, so multiple doses throughout the day help maintain consistent blood levels.
- Taking berberine with food can minimize potential gastrointestinal side effects like stomach upset or diarrhea.
Evidence-Based Recommendations
- The study published in 2024 1 found that berberine alone or in combination with hypoglycemic drugs significantly improved fasting plasma glucose, 2-h postprandial blood glucose, and other metabolic markers.
- The same study suggested that the most common BBR dosage was 0.9-1.5 g/d, with treatment cycles typically lasting 1-3 months.
- Other studies, such as the 2022 meta-analysis 2, also support the efficacy and safety of berberine in the treatment of type 2 diabetes mellitus.
Important Precautions
- If you're taking any medications, especially diabetes drugs, consult with a healthcare provider before starting berberine as it may interact with certain medications or affect blood sugar levels.
- Start with a lower dose and gradually increase if needed to assess your tolerance.
- Berberine works by activating an enzyme called AMPK, which helps regulate metabolism, improves insulin sensitivity, and supports healthy blood glucose levels.