From the Research
Aerococcus urinae infections are typically treated with nitrofurantoin as the first-line treatment, achieving clinical and microbiological success in 71/76% of cases of A. urinae UTI, as shown in a prospective observational study 1. The choice of antibiotic depends on the severity of the infection and the patient's underlying health conditions.
- For uncomplicated urinary tract infections caused by Aerococcus urinae, nitrofurantoin is recommended, with a success rate of 71/76% 1.
- For more severe infections or in patients with allergies to nitrofurantoin, alternatives include penicillin, amoxicillin, meropenem, ciprofloxacin, levofloxacin, rifampicin, and vancomycin, with susceptibility rates ranging from 79.2% to 100% 2.
- For complicated infections like bacteremia or endocarditis, combination therapy with penicillin plus an aminoglycoside may be necessary, although the effectiveness of this approach is not well established for Aerococcus urinae 3. It is essential to note that susceptibility testing is crucial, as resistance patterns can vary, and targeted therapy based on culture results is vital for effective treatment 4. Aerococcus urinae is a gram-positive coccus that can cause urinary tract infections, bacteremia, and endocarditis, particularly in elderly patients with underlying urological conditions, and is generally susceptible to beta-lactams but may show variable resistance to other antibiotics 5.