What are the risks of accidental D5LR (5% Dextrose in Lactated Ringer's solution) intrauterine infusion during amnioinfusion?

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Last updated: May 11, 2025View editorial policy

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From the Research

Accidental infusion of D5LR into the uterus during amnioinfusion poses significant risks to both the mother and the fetus, and normal saline is the preferred solution to avoid complications such as fluid overload, electrolyte imbalances, and potential fetal hyperglycemia. The primary concerns with using D5LR for amnioinfusion include fluid overload, electrolyte imbalances, and potential fetal hyperglycemia, as D5LR contains dextrose which can rapidly increase fetal glucose levels, potentially leading to fetal hyperinsulinemia and subsequent neonatal hypoglycemia after delivery 1. Some key points to consider when performing amnioinfusion include:

  • Solution selection: Normal saline (0.9% sodium chloride) is the preferred solution for amnioinfusion as it most closely resembles the electrolyte composition of amniotic fluid.
  • Infusion rate monitoring: Careful attention should be paid to infusion rate monitoring to prevent excessive fluid volume, which can lead to uterine overdistention, increasing the risk of uterine rupture, placental abruption, or amniotic fluid embolism.
  • Proper labeling of solutions: Proper labeling of all solutions is crucial to prevent accidental use of inappropriate fluids.
  • Double-checking protocols: Healthcare providers should implement double-checking protocols before connecting any solution to amnioinfusion lines.
  • Vigilant monitoring: Vigilant monitoring of maternal and fetal status throughout the procedure is necessary to detect any adverse effects early 2, 3. It is essential to prioritize the safety of both the mother and the fetus during amnioinfusion, and using normal saline as the preferred solution can help minimize the risks associated with this procedure 4, 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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