What are the treatment options for Hepatitis C?

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Last updated: February 19, 2025 • View editorial policy

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From the Guidelines

Treatment Options for Hepatitis C

The primary treatment options for Hepatitis C include Direct-Acting Antivirals (DAAs), which have revolutionized the treatment of this condition by offering high cure rates with shorter treatment durations and fewer side effects compared to older therapies 1.

Available Treatment Regimens

  • Ledipasvir/Sofosbuvir (Harvoni): 1 tablet (90mg/400mg) orally once daily for 8-12 weeks
  • Sofosbuvir/Velpatasvir (Epclusa): 1 tablet (400mg/100mg) orally once daily for 12 weeks
  • Sofosbuvir (Sovaldi): 1 tablet (400mg) orally once daily, often used in combination with other medications for 12-24 weeks
  • Daclatasvir (Daklinza): 1 tablet (60mg) orally once daily, often used in combination with other medications for 12 weeks
  • Ribavirin (Copegus, Rebetol, Ribasphere): 1-2 tablets (200-400mg) orally twice daily, often used in combination with other medications for 12-24 weeks
  • Glecaprevir/Pibrentasvir (Mavyret): 3 tablets (100mg/40mg) orally once daily for 8-12 weeks
  • Elbasvir/Grazoprevir (Zepatier): 1 tablet (50mg/100mg) orally once daily for 12 weeks

Considerations for Treatment Selection

The choice of treatment regimen should be individualized based on factors such as the genotype of the Hepatitis C virus, the presence and severity of liver damage (including cirrhosis), and other health factors. For patients with decompensated cirrhosis, the fixed-dose combination of sofosbuvir and velpatasvir is recommended as the treatment of choice due to its safety profile and efficacy in this patient population 1.

Monitoring and Follow-Up

It is crucial to monitor patients for sustained virologic response (SVR) at 12 and 24 weeks after treatment completion, as late relapses can occur 1.

Consultation with a Healthcare Professional

Given the complexity of Hepatitis C treatment and the variety of available regimens, it is essential to consult a healthcare professional for personalized treatment recommendations. They can help determine the most effective treatment plan based on the individual's specific condition and health status.

From the FDA Drug Label

Ledipasvir and sofosbuvir 12 Weeks (336) Ledipasvir and sofosbuvir + RBV 12 Weeks (336) Ledipasvir and sofosbuvir 24 Weeks (1) Ledipasvir and sofosbuvir + RBV 24 weeks (334) Ledipasvir and sofosbuvir 8 Weeks (45) Ledipasvir and sofosbuvir 12 Weeks (12) Ledipasvir and sofosbuvir 24 Weeks (6)

The treatment options for Hepatitis C include:

  • Ledipasvir and sofosbuvir for 8,12, or 24 weeks
  • Ledipasvir and sofosbuvir + ribavirin (RBV) for 12 or 24 weeks 2

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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