Differential Diagnosis for TTP
- Single most likely diagnosis
- Thrombotic Thrombocytopenic Purpura (TTP): This is the most likely diagnosis given the acronym "TTP" in the question. TTP is a rare blood disorder characterized by the formation of blood clots in small blood vessels throughout the body, which can lead to low platelet counts, microangiopathic hemolytic anemia, and organ dysfunction.
- Other Likely diagnoses
- Hemolytic Uremic Syndrome (HUS): HUS is another disorder that presents with similar symptoms to TTP, including microangiopathic hemolytic anemia and thrombocytopenia, but it is more commonly associated with acute kidney injury.
- Disseminated Intravascular Coagulation (DIC): DIC is a condition characterized by the widespread formation of blood clots in small blood vessels, which can lead to organ dysfunction and bleeding complications.
- Do Not Miss
- Malignant Hypertension: This condition can cause microvascular thrombi and organ damage, similar to TTP, and is essential to recognize due to its potential for severe complications.
- Sickle Cell Disease with Sickle Cell Crisis: Sickle cell disease can cause microvascular occlusion and organ damage, and it is crucial to consider this diagnosis in patients with a history of sickle cell disease.
- Antiphospholipid Syndrome: This autoimmune disorder can cause blood clots in small and large vessels, and it is essential to recognize due to its potential for severe complications.
- Rare diagnoses
- Atypical HUS (aHUS): aHUS is a rare disorder that presents with similar symptoms to TTP and HUS, but it is not typically associated with diarrhea or infection.
- Thrombotic Microangiopathy (TMA) associated with pregnancy or postpartum: TMA can occur in pregnant or postpartum women and presents with similar symptoms to TTP.
- Cobalamin C deficiency: This rare genetic disorder can cause homocystinuria, which can lead to thrombotic microangiopathy and symptoms similar to TTP.