From the Research
The most common source of metastatic small bowel tumor is melanoma (option b). Melanoma has a unique propensity to metastasize to the small intestine compared to other primary malignancies. While lung, breast, and soft tissue sarcomas can all metastasize to the small bowel, melanoma does so with greater frequency. This occurs because melanoma cells have a particular affinity for the rich vascular supply of the small intestine and can spread hematogenously throughout the gastrointestinal tract. Melanoma metastases to the small bowel often present with symptoms such as abdominal pain, gastrointestinal bleeding, obstruction, or intussusception. The diagnosis is typically confirmed through imaging studies like CT scans followed by endoscopy and biopsy. Treatment usually involves surgical resection of the metastatic lesion when possible, along with systemic therapy for the underlying melanoma. According to a recent study 1, metastasectomy for small bowel metastasis in melanoma patients is safe and appears to promote long-term survival and enhanced quality of life. Another study 2 also supports the role of surgical treatment in patients with small bowel metastases from melanoma, showing that it may increase survival, especially when combined with novel therapies.
Some key points to consider in the management of metastatic small bowel tumors from melanoma include:
- The importance of early diagnosis and treatment to improve outcomes 3, 4
- The role of surgical resection in relieving symptoms and prolonging life 5
- The potential benefits of combining surgery with systemic therapy, including novel immunotherapeutic agents 1, 2
- The need for a multidisciplinary approach to achieve effective results in the treatment of metastatic melanoma 2