What are the differential diagnoses, imaging tests, and treatments for shoulder pain (shoulder discomfort)?

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Last updated: May 12, 2025View editorial policy

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Differential Diagnosis for Shoulder Pain

The differential diagnosis for shoulder pain can be categorized into the following groups:

  • Single Most Likely Diagnosis
    • Rotator Cuff Tendinitis: This is the most common cause of shoulder pain, often resulting from overuse or repetitive strain on the rotator cuff muscles and tendons. Justification: The rotator cuff is a common area for wear and tear, and tendinitis can cause significant pain and limited mobility.
  • Other Likely Diagnoses
    • Adhesive Capsulitis (Frozen Shoulder): Characterized by stiffness and limited range of motion in the shoulder joint, often following trauma or inflammation. Justification: Frozen shoulder is a common condition that can cause significant pain and disability.
    • Bursitis: Inflammation of the bursae, fluid-filled sacs that cushion the joints, can cause pain and swelling in the shoulder. Justification: Bursitis is a common condition that can be caused by repetitive motion or direct trauma to the shoulder.
    • Labral Tears: Tears in the labrum, a cartilaginous structure surrounding the shoulder socket, can cause pain and instability. Justification: Labral tears can be caused by trauma or repetitive motion, and can be a source of significant pain.
  • Do Not Miss Diagnoses
    • Fracture: A fracture of the humerus, scapula, or clavicle can cause severe pain and limited mobility. Justification: Fractures can be life-threatening if not promptly diagnosed and treated, especially in older adults or those with osteoporosis.
    • Septic Arthritis: Bacterial infection of the shoulder joint can cause severe pain, swelling, and limited mobility. Justification: Septic arthritis is a medical emergency that requires prompt diagnosis and treatment to prevent joint destruction and systemic infection.
    • Thoracic Outlet Syndrome: Compression of the nerves and blood vessels in the thoracic outlet can cause pain, numbness, and tingling in the shoulder and arm. Justification: Thoracic outlet syndrome can be a source of significant pain and disability, and can be caused by a variety of factors, including trauma or anatomical abnormalities.
  • Rare Diagnoses
    • Osteonecrosis: Death of bone tissue due to lack of blood supply can cause pain and limited mobility in the shoulder. Justification: Osteonecrosis is a rare condition that can be caused by trauma, steroid use, or other factors.
    • Tumors: Benign or malignant tumors of the bone or soft tissue can cause pain and limited mobility in the shoulder. Justification: Tumors are a rare cause of shoulder pain, but can be life-threatening if not promptly diagnosed and treated.
    • Inflammatory Arthritis: Conditions such as rheumatoid arthritis or lupus can cause pain, swelling, and limited mobility in the shoulder. Justification: Inflammatory arthritis is a rare cause of shoulder pain, but can be a source of significant disability and requires prompt diagnosis and treatment.

Imaging Tests

Imaging tests that may be used to diagnose shoulder pain include:

  • X-rays: To evaluate for fractures, osteoarthritis, or other bony abnormalities.
  • MRI: To evaluate for soft tissue injuries, such as rotator cuff tears or labral tears.
  • CT scans: To evaluate for fractures or other bony abnormalities.
  • Ultrasound: To evaluate for soft tissue injuries or to guide injections.

Treatments

Treatments for shoulder pain depend on the underlying diagnosis and may include:

  • Physical therapy: To improve range of motion and strength.
  • Medications: Such as NSAIDs or corticosteroids to reduce pain and inflammation.
  • Injections: Such as corticosteroids or platelet-rich plasma to reduce pain and inflammation.
  • Surgery: To repair or replace damaged tissues, such as rotator cuff repairs or joint replacements.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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